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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 29.09
Human Site: S1413 Identified Species: 45.71
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 S1413 G E D E F V P S D G L D K D E
Chimpanzee Pan troglodytes XP_516332 1634 184611 S1421 G E D E F V P S D G L D K D E
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 S1407 G E D E F V P S D G L D K D E
Dog Lupus familis XP_534241 2041 231068 S1830 G E D E F V P S D G L D K D E
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 S1400 G E D E F V P S D G L D K D E
Rat Rattus norvegicus P41516 1526 173202 T1323 A A T K A K F T A D L D S D D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 S1713 R E D D F I P S D S L D K D E
Chicken Gallus gallus O42131 1627 183228 S1419 R E D E F V P S D S V E K D E
Frog Xenopus laevis NP_001082502 1579 178601 V1375 D S E D E S F V I A K P I K K
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 S1405 A S A S P V H S F K N T E Q H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 M1244 T E E I I K K M A A A A K V A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 D1317 K V K K E G Q D I K K F M S P
Sea Urchin Strong. purpuratus XP_783546 1448 163750 T1245 K L L T R E E T K P S P Y G R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 N1270 H S A M D T D N N V A E V V K
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 N1225 K I K L E D K N F E R I L L E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 20 N.A. 73.3 73.3 0 13.3 N.A. 13.3 N.A. 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 40 N.A. 86.6 86.6 20 20 N.A. 20 N.A. 6.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 14 0 7 0 0 0 14 14 14 7 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 47 14 7 7 7 7 47 7 0 47 0 54 7 % D
% Glu: 0 54 14 40 20 7 7 0 0 7 0 14 7 0 54 % E
% Phe: 0 0 0 0 47 0 14 0 14 0 0 7 0 0 0 % F
% Gly: 34 0 0 0 0 7 0 0 0 34 0 0 0 7 0 % G
% His: 7 0 0 0 0 0 7 0 0 0 0 0 0 0 7 % H
% Ile: 0 7 0 7 7 7 0 0 14 0 0 7 7 0 0 % I
% Lys: 20 0 14 14 0 14 14 0 7 14 14 0 54 7 14 % K
% Leu: 0 7 7 7 0 0 0 0 0 0 47 0 7 7 0 % L
% Met: 0 0 0 7 0 0 0 7 0 0 0 0 7 0 0 % M
% Asn: 0 0 0 0 0 0 0 14 7 0 7 0 0 0 0 % N
% Pro: 0 0 0 0 7 0 47 0 0 7 0 14 0 0 7 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 0 % Q
% Arg: 14 0 0 0 7 0 0 0 0 0 7 0 0 0 7 % R
% Ser: 0 20 0 7 0 7 0 54 0 14 7 0 7 7 0 % S
% Thr: 7 0 7 7 0 7 0 14 0 0 0 7 0 0 0 % T
% Val: 0 7 0 0 0 47 0 7 0 7 7 0 7 14 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _