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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 18.18
Human Site: S1576 Identified Species: 28.57
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 S1576 S K K P K K T S F D Q D S D V
Chimpanzee Pan troglodytes XP_516332 1634 184611 S1584 S K K P K K T S F D Q D S D V
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 S1570 S K K P K K T S F D Q D S D V
Dog Lupus familis XP_534241 2041 231068 S1992 S K K P K K T S F D Q D S D V
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 S1563 S K K P K K T S F D Q D S D V
Rat Rattus norvegicus P41516 1526 173202 A1482 E K A I S K G A T S K K L K G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 A1875 P S K K S K K A S F D Q D S D
Chicken Gallus gallus O42131 1627 183228 A1579 P C K K S K K A A F D Q D S D
Frog Xenopus laevis NP_001082502 1579 178601 R1535 T T A A A K K R K P M E D D S
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 A1568 S R K P K K A A S D D E D D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 R1403 S P K R P A K R G R E D E S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 E1476 G S D D E D D E S F V V A P R
Sea Urchin Strong. purpuratus XP_783546 1448 163750 R1404 A Q T D R G P R R A A A S T K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 G1429 N S S S E K S G G D V S A I S
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 R1384 A I P Q R S R R Q R S S R A A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 13.3 13.3 13.3 46.6 N.A. 20 N.A. 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 26.6 N.A. 20 20 26.6 66.6 N.A. 26.6 N.A. 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 0 14 7 7 7 7 27 7 7 7 7 14 7 7 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 14 0 7 7 0 0 47 20 40 27 47 20 % D
% Glu: 7 0 0 0 14 0 0 7 0 0 7 14 7 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 34 20 0 0 0 0 0 % F
% Gly: 7 0 0 0 0 7 7 7 14 0 0 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 7 0 0 0 0 0 0 0 0 0 7 0 % I
% Lys: 0 40 60 14 40 74 27 0 7 0 7 7 0 7 7 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 14 7 7 40 7 0 7 0 0 7 0 0 0 7 0 % P
% Gln: 0 7 0 7 0 0 0 0 7 0 34 14 0 0 0 % Q
% Arg: 0 7 0 7 14 0 7 27 7 14 0 0 7 0 7 % R
% Ser: 47 20 7 7 20 7 7 34 20 7 7 14 40 20 20 % S
% Thr: 7 7 7 0 0 0 34 0 7 0 0 0 0 7 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 14 7 0 0 34 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _