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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
41.21
Human Site:
S548
Identified Species:
64.76
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S548
K
S
Y
D
D
A
E
S
L
K
T
L
R
Y
G
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S556
K
S
Y
D
D
A
K
S
L
K
T
L
R
Y
G
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S542
K
S
Y
D
D
A
E
S
L
K
T
L
R
Y
G
Dog
Lupus familis
XP_534241
2041
231068
S966
K
S
Y
D
D
A
E
S
L
K
T
L
R
Y
G
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S536
K
S
Y
D
D
A
E
S
L
K
T
L
R
Y
G
Rat
Rattus norvegicus
P41516
1526
173202
S525
K
N
Y
E
D
E
D
S
L
K
T
L
R
Y
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S851
K
S
Y
E
D
A
E
S
L
K
T
L
R
Y
G
Chicken
Gallus gallus
O42131
1627
183228
S553
K
S
Y
E
D
P
E
S
L
K
S
L
R
Y
G
Frog
Xenopus laevis
NP_001082502
1579
178601
S525
K
N
Y
D
D
N
E
S
L
R
T
L
R
Y
G
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S547
K
S
Y
D
D
P
E
S
L
K
S
L
R
Y
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
G454
S
L
A
V
S
G
L
G
V
I
G
R
D
L
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
N527
P
L
R
G
K
L
L
N
V
R
E
G
N
M
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
S455
L
D
K
K
C
H
T
S
K
H
S
K
I
K
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
Y480
R
S
V
L
G
N
N
Y
C
G
V
F
P
L
R
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
A435
K
L
E
D
A
N
K
A
G
T
K
E
G
Y
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
93.3
100
100
N.A.
100
73.3
N.A.
93.3
80
80
86.6
N.A.
0
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
100
93.3
93.3
93.3
N.A.
6.6
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
40
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
7
0
54
67
0
7
0
0
0
0
0
7
0
0
% D
% Glu:
0
0
7
20
0
7
54
0
0
0
7
7
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
7
7
7
0
7
7
7
7
7
7
0
74
% G
% His:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% I
% Lys:
74
0
7
7
7
0
14
0
7
60
7
7
0
7
14
% K
% Leu:
7
20
0
7
0
7
14
0
67
0
0
67
0
14
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
14
0
0
0
20
7
7
0
0
0
0
7
0
0
% N
% Pro:
7
0
0
0
0
14
0
0
0
0
0
0
7
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
7
0
0
0
0
0
0
14
0
7
67
0
7
% R
% Ser:
7
60
0
0
7
0
0
74
0
0
20
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
7
0
0
7
54
0
0
0
0
% T
% Val:
0
0
7
7
0
0
0
0
14
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
67
0
0
0
0
7
0
0
0
0
0
74
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _