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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
37.27
Human Site:
S976
Identified Species:
58.57
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S976
D
K
T
P
A
L
I
S
D
Y
K
E
Y
H
T
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S984
D
K
T
P
A
L
I
S
D
Y
K
E
Y
H
T
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S970
D
K
T
P
A
L
I
S
D
Y
K
E
Y
H
T
Dog
Lupus familis
XP_534241
2041
231068
S1394
D
K
T
P
A
L
I
S
D
Y
K
E
Y
H
T
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S964
D
K
T
P
A
L
I
S
D
Y
K
E
Y
H
T
Rat
Rattus norvegicus
P41516
1526
173202
Q931
L
P
I
R
T
W
T
Q
T
Y
K
E
Q
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S1279
D
K
T
P
A
L
I
S
D
Y
K
E
Y
H
T
Chicken
Gallus gallus
O42131
1627
183228
S981
E
K
T
P
A
L
I
S
D
Y
K
E
Y
H
T
Frog
Xenopus laevis
NP_001082502
1579
178601
T953
E
K
T
P
P
L
I
T
D
Y
K
E
Y
H
T
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S975
D
K
T
P
P
L
I
S
D
Y
K
E
Y
H
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
I852
S
N
Y
N
P
R
E
I
M
K
N
L
R
K
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
P925
E
P
Q
K
A
L
A
P
W
Y
K
N
F
R
G
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
S853
H
H
D
D
P
L
L
S
Y
M
Y
D
D
N
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
D878
G
E
S
M
V
P
M
D
P
W
Y
R
G
F
K
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
I833
L
V
N
G
A
E
G
I
G
T
G
W
S
T
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
20
N.A.
100
93.3
80
93.3
N.A.
0
N.A.
26.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
100
93.3
93.3
N.A.
0
N.A.
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
60
0
7
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
7
7
0
0
0
7
60
0
0
7
7
0
0
% D
% Glu:
20
7
0
0
0
7
7
0
0
0
0
67
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% F
% Gly:
7
0
0
7
0
0
7
0
7
0
7
0
7
0
7
% G
% His:
7
7
0
0
0
0
0
0
0
0
0
0
0
60
0
% H
% Ile:
0
0
7
0
0
0
60
14
0
0
0
0
0
0
0
% I
% Lys:
0
60
0
7
0
0
0
0
0
7
74
0
0
7
7
% K
% Leu:
14
0
0
0
0
74
7
0
0
0
0
7
0
0
7
% L
% Met:
0
0
0
7
0
0
7
0
7
7
0
0
0
0
7
% M
% Asn:
0
7
7
7
0
0
0
0
0
0
7
7
0
7
0
% N
% Pro:
0
14
0
60
27
7
0
7
7
0
0
0
0
0
0
% P
% Gln:
0
0
7
0
0
0
0
7
0
0
0
0
7
0
7
% Q
% Arg:
0
0
0
7
0
7
0
0
0
0
0
7
7
7
0
% R
% Ser:
7
0
7
0
0
0
0
60
0
0
0
0
7
0
0
% S
% Thr:
0
0
60
0
7
0
7
7
7
7
0
0
0
7
60
% T
% Val:
0
7
0
0
7
0
0
0
0
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
7
0
0
7
7
0
7
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
7
74
14
0
60
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _