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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 33.03
Human Site: T1137 Identified Species: 51.9
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 T1137 D S S S D S G T P S G P D F N
Chimpanzee Pan troglodytes XP_516332 1634 184611 T1145 D S S S D S G T P S G P D F N
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 T1131 D S S S D S G T P S G P D F N
Dog Lupus familis XP_534241 2041 231068 T1555 D S S S D S G T P S G P D F N
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 T1125 D S S S D S G T P S G P D F N
Rat Rattus norvegicus P41516 1526 173202 Y1080 K V L I Q R G Y D S D P V K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 T1440 D S S S D S G T T T G P D F N
Chicken Gallus gallus O42131 1627 183228 S1142 D A S S A S G S T S G P D F N
Frog Xenopus laevis NP_001082502 1579 178601 T1111 E E A E A N A T G P D F N Y L
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 S1136 D S S V D S G S F S G P N F N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 L1001 F P T A I D I L K E Y Y K L R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 L1074 V Q R K E Y L L G V L Q A Q S
Sea Urchin Strong. purpuratus XP_783546 1448 163750 R1002 V V K M N E D R L L R G E E E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 V1027 Y E K R K E T V V K N M E I E
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 G982 M V A F D P H G K I K K Y N S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 20 N.A. 86.6 73.3 6.6 73.3 N.A. 0 N.A. 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 93.3 86.6 40 86.6 N.A. 13.3 N.A. 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 14 7 14 0 7 0 0 0 0 0 7 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 54 0 0 0 54 7 7 0 7 0 14 0 47 0 0 % D
% Glu: 7 14 0 7 7 14 0 0 0 7 0 0 14 7 14 % E
% Phe: 7 0 0 7 0 0 0 0 7 0 0 7 0 54 0 % F
% Gly: 0 0 0 0 0 0 60 7 14 0 54 7 0 0 0 % G
% His: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 7 0 7 0 0 7 0 0 0 7 0 % I
% Lys: 7 0 14 7 7 0 0 0 14 7 7 7 7 7 0 % K
% Leu: 0 0 7 0 0 0 7 14 7 7 7 0 0 7 7 % L
% Met: 7 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 0 0 7 7 0 0 0 0 7 0 14 7 54 % N
% Pro: 0 7 0 0 0 7 0 0 34 7 0 60 0 0 0 % P
% Gln: 0 7 0 0 7 0 0 0 0 0 0 7 0 7 0 % Q
% Arg: 0 0 7 7 0 7 0 7 0 0 7 0 0 0 7 % R
% Ser: 0 47 54 47 0 54 0 14 0 54 0 0 0 0 14 % S
% Thr: 0 0 7 0 0 0 7 47 14 7 0 0 0 0 0 % T
% Val: 14 20 0 7 0 0 0 7 7 7 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 7 0 7 0 0 7 7 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _