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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
20.61
Human Site:
T1267
Identified Species:
32.38
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
T1267
K
K
K
G
D
L
D
T
A
A
V
K
V
E
F
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1275
K
K
K
G
D
L
D
T
A
A
V
K
V
E
F
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1261
K
K
K
G
D
L
D
T
T
A
V
K
V
E
F
Dog
Lupus familis
XP_534241
2041
231068
T1685
K
K
K
G
D
L
D
T
T
A
V
K
V
E
F
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
T1255
K
K
K
G
D
P
D
T
T
V
V
K
V
E
F
Rat
Rattus norvegicus
P41516
1526
173202
L1190
K
Q
D
E
Q
V
G
L
P
G
K
G
V
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
P1571
K
K
K
G
D
I
D
P
M
A
I
K
M
E
F
Chicken
Gallus gallus
O42131
1627
183228
S1273
K
K
K
G
D
A
D
S
V
A
I
K
M
E
F
Frog
Xenopus laevis
NP_001082502
1579
178601
V1239
K
K
I
K
G
E
D
V
A
K
K
M
E
F
D
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
D1266
K
K
K
K
G
E
I
D
A
A
V
K
L
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
E1111
K
E
K
E
V
D
P
E
K
A
F
K
K
L
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
L1184
V
G
M
A
L
I
K
L
S
E
E
E
K
N
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
D1112
T
S
R
G
Y
D
S
D
P
V
K
A
W
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
L1137
I
E
K
V
E
E
L
L
A
D
R
D
K
M
I
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
E1092
A
T
S
D
E
E
D
E
E
S
S
H
E
D
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
93.3
93.3
N.A.
80
13.3
N.A.
66.6
66.6
26.6
53.3
N.A.
26.6
N.A.
0
6.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
80
33.3
N.A.
86.6
86.6
26.6
60
N.A.
33.3
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
7
0
0
34
54
0
7
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
47
14
60
14
0
7
0
7
0
7
7
% D
% Glu:
0
14
0
14
14
27
0
14
7
7
7
7
14
54
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
47
% F
% Gly:
0
7
0
54
14
0
7
0
0
7
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
7
0
7
0
0
14
7
0
0
0
14
0
0
0
14
% I
% Lys:
74
60
67
14
0
0
7
0
7
7
20
60
20
14
7
% K
% Leu:
0
0
0
0
7
27
7
20
0
0
0
0
7
7
0
% L
% Met:
0
0
7
0
0
0
0
0
7
0
0
7
14
7
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% N
% Pro:
0
0
0
0
0
7
7
7
14
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
7
0
0
0
0
0
0
0
7
0
0
0
0
% R
% Ser:
0
7
7
0
0
0
7
7
7
7
7
0
0
0
0
% S
% Thr:
7
7
0
0
0
0
0
34
20
0
0
0
0
0
14
% T
% Val:
7
0
0
7
7
7
0
7
7
14
40
0
40
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _