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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
11.52
Human Site:
T1292
Identified Species:
18.1
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
T1292
G
A
G
E
E
A
L
T
P
S
V
P
I
N
K
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1300
G
A
G
E
E
A
L
T
P
S
V
P
I
N
K
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
I1286
G
A
G
E
E
A
L
I
P
S
A
P
I
N
K
Dog
Lupus familis
XP_534241
2041
231068
I1710
G
T
G
E
E
A
L
I
P
S
A
P
V
N
K
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
T1280
G
T
G
E
E
T
L
T
P
S
A
P
V
N
K
Rat
Rattus norvegicus
P41516
1526
173202
R1215
L
P
S
P
V
G
K
R
V
I
P
Q
V
T
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
T1596
G
A
E
D
P
L
N
T
S
A
P
V
P
K
T
Chicken
Gallus gallus
O42131
1627
183228
N1298
G
G
G
D
D
T
V
N
T
A
A
S
G
T
K
Frog
Xenopus laevis
NP_001082502
1579
178601
G1264
S
P
E
Q
S
P
E
G
L
T
L
A
E
R
L
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
P1291
G
E
N
S
L
I
S
P
S
G
L
P
N
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
E1136
M
S
M
W
M
L
T
E
E
K
K
N
E
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1209
E
V
R
V
I
E
K
K
T
W
Q
D
L
W
H
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
S1137
D
S
F
D
D
A
A
S
D
S
S
E
A
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
D1162
P
K
S
L
W
L
S
D
L
E
S
L
D
K
E
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L1117
Y
G
T
Y
E
Y
L
L
G
M
R
I
W
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
86.6
73.3
N.A.
73.3
0
N.A.
20
20
0
13.3
N.A.
0
N.A.
0
13.3
P-Site Similarity:
100
100
86.6
80
N.A.
80
6.6
N.A.
33.3
46.6
20
20
N.A.
6.6
N.A.
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
27
0
0
0
34
7
0
0
14
27
7
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
20
14
0
0
7
7
0
0
7
7
0
0
% D
% Glu:
7
7
14
34
40
7
7
7
7
7
0
7
14
0
7
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
54
14
40
0
0
7
0
7
7
7
0
0
7
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
7
7
0
14
0
7
0
7
20
0
0
% I
% Lys:
0
7
0
0
0
0
14
7
0
7
7
0
0
14
40
% K
% Leu:
7
0
0
7
7
20
40
7
14
0
14
7
7
7
20
% L
% Met:
7
0
7
0
7
0
0
0
0
7
0
0
0
0
7
% M
% Asn:
0
0
7
0
0
0
7
7
0
0
0
7
7
34
0
% N
% Pro:
7
14
0
7
7
7
0
7
34
0
14
40
7
7
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
7
7
0
0
0
% Q
% Arg:
0
0
7
0
0
0
0
7
0
0
7
0
0
7
0
% R
% Ser:
7
14
14
7
7
0
14
7
14
40
14
7
0
7
7
% S
% Thr:
0
14
7
0
0
14
7
27
14
7
0
0
0
14
7
% T
% Val:
0
7
0
7
7
0
7
0
7
0
14
7
20
0
0
% V
% Trp:
0
0
0
7
7
0
0
0
0
7
0
0
7
7
0
% W
% Tyr:
7
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _