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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 11.52
Human Site: T1292 Identified Species: 18.1
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 T1292 G A G E E A L T P S V P I N K
Chimpanzee Pan troglodytes XP_516332 1634 184611 T1300 G A G E E A L T P S V P I N K
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 I1286 G A G E E A L I P S A P I N K
Dog Lupus familis XP_534241 2041 231068 I1710 G T G E E A L I P S A P V N K
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 T1280 G T G E E T L T P S A P V N K
Rat Rattus norvegicus P41516 1526 173202 R1215 L P S P V G K R V I P Q V T M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 T1596 G A E D P L N T S A P V P K T
Chicken Gallus gallus O42131 1627 183228 N1298 G G G D D T V N T A A S G T K
Frog Xenopus laevis NP_001082502 1579 178601 G1264 S P E Q S P E G L T L A E R L
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 P1291 G E N S L I S P S G L P N P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 E1136 M S M W M L T E E K K N E L L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 K1209 E V R V I E K K T W Q D L W H
Sea Urchin Strong. purpuratus XP_783546 1448 163750 S1137 D S F D D A A S D S S E A G S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 D1162 P K S L W L S D L E S L D K E
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 L1117 Y G T Y E Y L L G M R I W S L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 86.6 73.3 N.A. 73.3 0 N.A. 20 20 0 13.3 N.A. 0 N.A. 0 13.3
P-Site Similarity: 100 100 86.6 80 N.A. 80 6.6 N.A. 33.3 46.6 20 20 N.A. 6.6 N.A. 6.6 40
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 27 0 0 0 34 7 0 0 14 27 7 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 20 14 0 0 7 7 0 0 7 7 0 0 % D
% Glu: 7 7 14 34 40 7 7 7 7 7 0 7 14 0 7 % E
% Phe: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 54 14 40 0 0 7 0 7 7 7 0 0 7 7 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % H
% Ile: 0 0 0 0 7 7 0 14 0 7 0 7 20 0 0 % I
% Lys: 0 7 0 0 0 0 14 7 0 7 7 0 0 14 40 % K
% Leu: 7 0 0 7 7 20 40 7 14 0 14 7 7 7 20 % L
% Met: 7 0 7 0 7 0 0 0 0 7 0 0 0 0 7 % M
% Asn: 0 0 7 0 0 0 7 7 0 0 0 7 7 34 0 % N
% Pro: 7 14 0 7 7 7 0 7 34 0 14 40 7 7 0 % P
% Gln: 0 0 0 7 0 0 0 0 0 0 7 7 0 0 0 % Q
% Arg: 0 0 7 0 0 0 0 7 0 0 7 0 0 7 0 % R
% Ser: 7 14 14 7 7 0 14 7 14 40 14 7 0 7 7 % S
% Thr: 0 14 7 0 0 14 7 27 14 7 0 0 0 14 7 % T
% Val: 0 7 0 7 7 0 7 0 7 0 14 7 20 0 0 % V
% Trp: 0 0 0 7 7 0 0 0 0 7 0 0 7 7 0 % W
% Tyr: 7 0 0 7 0 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _