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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
18.48
Human Site:
Y85
Identified Species:
29.05
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
Y85
L
T
Q
F
M
W
V
Y
D
E
D
V
G
M
N
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y93
L
T
Q
F
M
W
V
Y
D
E
D
V
G
M
N
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
G85
W
V
Y
D
E
D
V
G
M
N
C
R
E
V
T
Dog
Lupus familis
XP_534241
2041
231068
Y503
L
T
Q
L
M
W
V
Y
D
E
D
V
G
M
N
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
E83
D
V
G
M
N
C
R
E
V
T
F
V
P
G
L
Rat
Rattus norvegicus
P41516
1526
173202
I83
F
V
P
G
L
Y
K
I
F
D
E
I
L
V
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
Y388
L
T
Q
L
M
W
V
Y
D
E
D
V
G
M
N
Chicken
Gallus gallus
O42131
1627
183228
Y90
L
T
Q
L
M
W
V
Y
D
E
D
V
G
M
N
Frog
Xenopus laevis
NP_001082502
1579
178601
F83
V
P
G
L
Y
K
I
F
D
E
I
L
V
N
A
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
F84
V
T
Q
Q
M
W
V
F
D
E
E
I
G
M
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
T37
Y
I
G
S
V
E
F
T
K
E
L
M
W
V
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
V97
T
E
K
T
P
M
W
V
Y
N
M
E
E
S
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
L38
L
N
D
D
I
A
D
L
P
E
M
G
G
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
W63
E
K
H
T
Q
T
L
W
V
Y
E
K
D
E
M
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L18
K
Y
Q
K
I
S
Q
L
E
H
I
L
K
R
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
6.6
93.3
N.A.
6.6
6.6
N.A.
93.3
93.3
13.3
66.6
N.A.
6.6
N.A.
0
20
P-Site Similarity:
100
100
13.3
93.3
N.A.
6.6
46.6
N.A.
93.3
93.3
40
93.3
N.A.
26.6
N.A.
6.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
0
7
14
0
7
7
0
47
7
34
0
7
0
7
% D
% Glu:
7
7
0
0
7
7
0
7
7
60
20
7
14
7
0
% E
% Phe:
7
0
0
14
0
0
7
14
7
0
7
0
0
0
0
% F
% Gly:
0
0
20
7
0
0
0
7
0
0
0
7
47
14
0
% G
% His:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
7
0
0
14
0
7
7
0
0
14
14
0
0
0
% I
% Lys:
7
7
7
7
0
7
7
0
7
0
0
7
7
0
7
% K
% Leu:
40
0
0
27
7
0
7
14
0
0
7
14
7
0
7
% L
% Met:
0
0
0
7
40
7
0
0
7
0
14
7
0
40
7
% M
% Asn:
0
7
0
0
7
0
0
0
0
14
0
0
0
7
47
% N
% Pro:
0
7
7
0
7
0
0
0
7
0
0
0
7
0
7
% P
% Gln:
0
0
47
7
7
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
7
0
0
0
0
7
0
7
0
% R
% Ser:
0
0
0
7
0
7
0
0
0
0
0
0
0
7
0
% S
% Thr:
7
40
0
14
0
7
0
7
0
7
0
0
0
0
7
% T
% Val:
14
20
0
0
7
0
47
7
14
0
0
40
7
20
0
% V
% Trp:
7
0
0
0
0
40
7
7
0
0
0
0
7
0
0
% W
% Tyr:
7
7
7
0
7
7
0
34
7
7
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _