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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HHEX
All Species:
14.55
Human Site:
S223
Identified Species:
32
UniProt:
Q03014
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03014
NP_002720.1
270
30022
S223
D
Q
R
Q
D
L
P
S
E
Q
N
K
G
A
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090597
270
30002
S223
D
Q
R
Q
D
L
P
S
E
Q
N
K
G
A
S
Dog
Lupus familis
XP_850204
270
29974
S223
C
D
Q
R
Q
D
L
S
S
E
Q
N
K
G
A
Cat
Felis silvestris
Mouse
Mus musculus
P43120
271
29968
S224
E
Q
G
Q
D
L
P
S
E
Q
N
K
G
A
S
Rat
Rattus norvegicus
A0JPN1
476
50008
E359
V
P
A
E
G
E
R
E
E
R
S
P
S
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q05502
277
30195
S229
G
D
P
R
S
E
G
S
P
S
P
A
G
G
G
Frog
Xenopus laevis
O13023
272
30558
S224
E
S
Q
E
R
C
L
S
A
E
Q
K
S
R
E
Zebra Danio
Brachydanio rerio
Q9IAV3
228
26030
P181
R
L
K
Q
E
N
P
P
S
T
G
K
R
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650938
323
34643
S277
V
G
S
P
S
S
A
S
S
S
S
V
P
V
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
S101
Y
L
S
S
S
D
R
S
E
L
A
K
R
L
D
Sea Urchin
Strong. purpuratus
XP_781292
310
34523
N263
E
I
K
A
H
Q
P
N
Q
Q
T
S
H
N
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
97.7
N.A.
92.6
25.6
N.A.
N.A.
75.8
73.5
63.3
N.A.
26
N.A.
24
42.5
Protein Similarity:
100
N.A.
98.1
98.1
N.A.
95.9
34.2
N.A.
N.A.
81.5
83.8
70.7
N.A.
40.5
N.A.
35.1
53.5
P-Site Identity:
100
N.A.
100
6.6
N.A.
86.6
13.3
N.A.
N.A.
13.3
13.3
20
N.A.
6.6
N.A.
20
13.3
P-Site Similarity:
100
N.A.
100
33.3
N.A.
93.3
33.3
N.A.
N.A.
20
40
40
N.A.
13.3
N.A.
20
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
10
0
10
0
10
10
0
28
19
% A
% Cys:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
19
19
0
0
28
19
0
0
0
0
0
0
0
0
10
% D
% Glu:
28
0
0
19
10
19
0
10
46
19
0
0
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
10
10
0
10
0
10
0
0
0
10
0
37
19
10
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
19
0
0
0
0
0
0
0
0
55
10
0
0
% K
% Leu:
0
19
0
0
0
28
19
0
0
10
0
0
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
10
0
0
28
10
0
10
0
% N
% Pro:
0
10
10
10
0
0
46
10
10
0
10
10
10
0
10
% P
% Gln:
0
28
19
37
10
10
0
0
10
37
19
0
0
0
0
% Q
% Arg:
10
0
19
19
10
0
19
0
0
10
0
0
19
19
0
% R
% Ser:
0
10
19
10
28
10
0
73
28
19
19
10
19
0
37
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
0
% T
% Val:
19
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _