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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HHEX
All Species:
20.3
Human Site:
Y110
Identified Species:
44.67
UniProt:
Q03014
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03014
NP_002720.1
270
30022
Y110
F
P
R
T
V
N
D
Y
T
H
A
L
L
R
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090597
270
30002
Y110
F
P
R
T
V
N
D
Y
T
H
A
L
L
R
H
Dog
Lupus familis
XP_850204
270
29974
Y111
F
P
R
T
V
N
D
Y
T
H
A
L
L
R
H
Cat
Felis silvestris
Mouse
Mus musculus
P43120
271
29968
Y111
F
P
R
T
V
N
D
Y
T
H
A
L
L
R
H
Rat
Rattus norvegicus
A0JPN1
476
50008
N243
P
L
S
S
N
P
R
N
S
V
Q
H
Q
F
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q05502
277
30195
A113
P
L
Y
S
F
P
R
A
V
G
D
Y
T
H
A
Frog
Xenopus laevis
O13023
272
30558
Y110
F
S
R
P
V
S
D
Y
T
H
A
L
I
R
H
Zebra Danio
Brachydanio rerio
Q9IAV3
228
26030
Q76
P
I
H
P
V
L
S
Q
Y
A
S
M
Y
P
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650938
323
34643
Q125
Y
Q
Q
V
L
Q
L
Q
K
N
P
S
L
F
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
Sea Urchin
Strong. purpuratus
XP_781292
310
34523
Y149
Y
P
Y
S
R
N
D
Y
P
H
S
F
L
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
97.7
N.A.
92.6
25.6
N.A.
N.A.
75.8
73.5
63.3
N.A.
26
N.A.
24
42.5
Protein Similarity:
100
N.A.
98.1
98.1
N.A.
95.9
34.2
N.A.
N.A.
81.5
83.8
70.7
N.A.
40.5
N.A.
35.1
53.5
P-Site Identity:
100
N.A.
100
100
N.A.
100
0
N.A.
N.A.
0
73.3
6.6
N.A.
6.6
N.A.
0
40
P-Site Similarity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
N.A.
6.6
86.6
20
N.A.
33.3
N.A.
0
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
10
46
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
55
0
0
0
10
0
0
10
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
46
0
0
0
10
0
0
0
0
0
0
10
0
19
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
55
0
10
0
10
46
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
0
19
0
0
10
10
10
0
0
0
0
46
55
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% M
% Asn:
0
0
0
0
10
46
0
10
0
10
0
0
0
0
0
% N
% Pro:
28
46
0
19
0
19
0
0
10
0
10
0
0
10
0
% P
% Gln:
0
10
10
0
0
10
0
19
0
0
10
0
10
0
10
% Q
% Arg:
0
0
46
0
10
0
19
0
0
0
0
0
0
46
10
% R
% Ser:
0
10
10
28
0
10
10
0
10
0
19
10
0
0
0
% S
% Thr:
0
0
0
37
0
0
0
0
46
0
0
0
10
0
0
% T
% Val:
0
0
0
10
55
0
0
0
10
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
19
0
19
0
0
0
0
55
10
0
0
10
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _