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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MECOM All Species: 27.58
Human Site: S552 Identified Species: 60.67
UniProt: Q03112 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03112 NP_001098548.2 1051 118276 S552 L Q K G S S E S P F D L T T K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001093705 1041 117066 S542 L Q K G S S E S P F D L T T K
Dog Lupus familis XP_545272 1312 147394 S808 L Q K G S S E S P F D L T T K
Cat Felis silvestris
Mouse Mus musculus P14404 1042 116829 S552 L Q K G S S E S P F D L T T K
Rat Rattus norvegicus NP_001099893 917 102087 P451 P A T S Q D Q P L D L S M G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514858 1260 141585 S770 I Q K G S S E S P F D L T T K
Chicken Gallus gallus XP_422804 1115 125799 S624 I P K G S S E S P F D L T T K
Frog Xenopus laevis B7ZRU9 1055 118966 S553 V Q K G K T E S P F D L T T K
Zebra Danio Brachydanio rerio XP_001922927 1153 129171 G625 Q K L H T A T G A D S P F D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121599 1541 171480 E1011 D E D E D S E E G G V P P G R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_798234 1723 193143 S1070 P Y P L S Y P S L A A H P S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.5 77.1 N.A. 92.4 79.5 N.A. 77.1 64.6 78.1 50.9 N.A. N.A. 20.1 N.A. 22.4
Protein Similarity: 100 N.A. 98.7 78 N.A. 95.2 82.2 N.A. 79.7 74 87.4 64.5 N.A. N.A. 34.5 N.A. 35.4
P-Site Identity: 100 N.A. 100 100 N.A. 100 0 N.A. 93.3 86.6 80 0 N.A. N.A. 13.3 N.A. 13.3
P-Site Similarity: 100 N.A. 100 100 N.A. 100 6.6 N.A. 100 93.3 93.3 20 N.A. N.A. 26.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 10 0 0 10 10 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 10 0 10 10 0 0 0 19 64 0 0 10 0 % D
% Glu: 0 10 0 10 0 0 73 10 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 64 0 0 10 0 0 % F
% Gly: 0 0 0 64 0 0 0 10 10 10 0 0 0 19 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 64 0 10 0 0 0 0 0 0 0 0 0 64 % K
% Leu: 37 0 10 10 0 0 0 0 19 0 10 64 0 0 19 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 19 10 10 0 0 0 10 10 64 0 0 19 19 0 0 % P
% Gln: 10 55 0 0 10 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % R
% Ser: 0 0 0 10 64 64 0 73 0 0 10 10 0 10 10 % S
% Thr: 0 0 10 0 10 10 10 0 0 0 0 0 64 64 0 % T
% Val: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 10 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _