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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MVK All Species: 12.73
Human Site: S384 Identified Species: 28
UniProt: Q03426 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03426 NP_000422.1 396 42451 S384 V S I H S A T S L D S R V Q Q
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001105759 396 42516 S384 V S I H S A T S L D S R V Q Q
Dog Lupus familis XP_543435 409 43821 S397 I S I H S A A S L D T Q V Q R
Cat Felis silvestris
Mouse Mus musculus Q9R008 395 41859 A384 V S T H S A A A V G D P V R Q
Rat Rattus norvegicus P17256 395 41969 S384 V S M H S A T S I E D P V R Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001231562 527 56812 A515 V T L H S S S A L N A E V L H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007350 396 42696 A384 V Q Q H S S A A I S P D V L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001022867 614 66051 P594 V V E H Q T R P E L F Q T P V
Sea Urchin Strong. purpuratus XP_790690 413 45125 E396 V M M H R S K E T L L G D G L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P46086 378 40625 A367 S G F Q C F T A L I G G N G A
Baker's Yeast Sacchar. cerevisiae P07277 443 48441 K402 G C C L L S A K N L N K D L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.2 81.9 N.A. 81 81.8 N.A. N.A. 28.6 N.A. 56.5 N.A. N.A. N.A. 27.5 46
Protein Similarity: 100 N.A. 96.7 87.5 N.A. 88.1 90.1 N.A. N.A. 41.7 N.A. 73.9 N.A. N.A. N.A. 39 63.4
P-Site Identity: 100 N.A. 100 66.6 N.A. 46.6 60 N.A. N.A. 33.3 N.A. 26.6 N.A. N.A. N.A. 13.3 13.3
P-Site Similarity: 100 N.A. 100 93.3 N.A. 66.6 86.6 N.A. N.A. 80 N.A. 53.3 N.A. N.A. N.A. 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. 36.6 32.7 N.A.
Protein Similarity: N.A. N.A. N.A. 57.5 53.2 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 46 37 37 0 0 10 0 0 0 10 % A
% Cys: 0 10 10 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 28 19 10 19 0 0 % D
% Glu: 0 0 10 0 0 0 0 10 10 10 0 10 0 0 0 % E
% Phe: 0 0 10 0 0 10 0 0 0 0 10 0 0 0 0 % F
% Gly: 10 10 0 0 0 0 0 0 0 10 10 19 0 19 0 % G
% His: 0 0 0 82 0 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 10 0 28 0 0 0 0 0 19 10 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 10 10 0 0 0 10 0 0 19 % K
% Leu: 0 0 10 10 10 0 0 0 46 28 10 0 0 28 10 % L
% Met: 0 10 19 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 10 10 0 10 0 0 % N
% Pro: 0 0 0 0 0 0 0 10 0 0 10 19 0 10 0 % P
% Gln: 0 10 10 10 10 0 0 0 0 0 0 19 0 28 37 % Q
% Arg: 0 0 0 0 10 0 10 0 0 0 0 19 0 19 10 % R
% Ser: 10 46 0 0 64 37 10 37 0 10 19 0 0 0 0 % S
% Thr: 0 10 10 0 0 10 37 0 10 0 10 0 10 0 0 % T
% Val: 73 10 0 0 0 0 0 0 10 0 0 0 64 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _