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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MVK All Species: 1.21
Human Site: S69 Identified Species: 2.67
UniProt: Q03426 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03426 NP_000422.1 396 42451 S69 W D V A R L Q S L D T S F L E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001105759 396 42516 L69 W D V A R L Q L L D T S F L E
Dog Lupus familis XP_543435 409 43821 L78 W D V A R L Q L Q D T S F L E
Cat Felis silvestris
Mouse Mus musculus Q9R008 395 41859 R69 W D V G M L Q R L D T S F L E
Rat Rattus norvegicus P17256 395 41969 L69 W D V A T L Q L L D T G F L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001231562 527 56812 G91 F K Y I H S N G I I S R E L K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007350 396 42696 L70 E I T A L Q P L L A G S K A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001022867 614 66051 D208 K D L L K A A D R L A A E Y P
Sea Urchin Strong. purpuratus XP_790690 413 45125 E79 W D V L E L Q E Q F R D L L N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P46086 378 40625 E71 W S L A R I K E A I P Y D S S
Baker's Yeast Sacchar. cerevisiae P07277 443 48441 T72 I N D F N A I T E D Q V N S Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.2 81.9 N.A. 81 81.8 N.A. N.A. 28.6 N.A. 56.5 N.A. N.A. N.A. 27.5 46
Protein Similarity: 100 N.A. 96.7 87.5 N.A. 88.1 90.1 N.A. N.A. 41.7 N.A. 73.9 N.A. N.A. N.A. 39 63.4
P-Site Identity: 100 N.A. 93.3 86.6 N.A. 80 80 N.A. N.A. 6.6 N.A. 26.6 N.A. N.A. N.A. 6.6 40
P-Site Similarity: 100 N.A. 93.3 86.6 N.A. 80 80 N.A. N.A. 33.3 N.A. 26.6 N.A. N.A. N.A. 26.6 40
Percent
Protein Identity: N.A. N.A. N.A. 36.6 32.7 N.A.
Protein Similarity: N.A. N.A. N.A. 57.5 53.2 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 55 0 19 10 0 10 10 10 10 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 64 10 0 0 0 0 10 0 55 0 10 10 0 0 % D
% Glu: 10 0 0 0 10 0 0 19 10 0 0 0 19 0 55 % E
% Phe: 10 0 0 10 0 0 0 0 0 10 0 0 46 0 0 % F
% Gly: 0 0 0 10 0 0 0 10 0 0 10 10 0 0 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 10 0 10 0 10 10 0 10 19 0 0 0 0 0 % I
% Lys: 10 10 0 0 10 0 10 0 0 0 0 0 10 0 10 % K
% Leu: 0 0 19 19 10 55 0 37 46 10 0 0 10 64 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 0 10 0 10 0 0 0 0 0 10 0 10 % N
% Pro: 0 0 0 0 0 0 10 0 0 0 10 0 0 0 10 % P
% Gln: 0 0 0 0 0 10 55 0 19 0 10 0 0 0 10 % Q
% Arg: 0 0 0 0 37 0 0 10 10 0 10 10 0 0 0 % R
% Ser: 0 10 0 0 0 10 0 10 0 0 10 46 0 19 10 % S
% Thr: 0 0 10 0 10 0 0 10 0 0 46 0 0 0 0 % T
% Val: 0 0 55 0 0 0 0 0 0 0 0 10 0 0 0 % V
% Trp: 64 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 10 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _