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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC6 All Species: 10
Human Site: S1085 Identified Species: 18.33
UniProt: Q03468 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03468 NP_000115.1 1493 168416 S1085 A E V N A V T S N R S D P L K
Chimpanzee Pan troglodytes XP_507781 1491 168031 S1083 A E V N A V T S N R S D P L K
Rhesus Macaque Macaca mulatta XP_001107536 1496 168876 S1088 A E V N V V P S N Q S D P L K
Dog Lupus familis XP_534944 1486 168108 I1078 K G A G V N T I T S D Q G D P
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus NP_001100766 1325 148468 C938 S N I Q T L K C H F K K R T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508174 968 109820 A581 N P S T D T Q A R E R A W R I
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24368 1027 118855 L640 T A E Q K A A L D S L G E S S
Honey Bee Apis mellifera XP_001120586 932 107557 L545 V G G L G V N L T G A N R V V
Nematode Worm Caenorhab. elegans P41877 1009 116656 D622 A K D S T I S D D D I D T I L
Sea Urchin Strong. purpuratus XP_001193315 953 107227 L566 V V Q R E L L L K K K M E A D
Poplar Tree Populus trichocarpa XP_002307656 1206 134941 G818 I L T T K V G G L G T N L T G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWY3 1057 122611 S670 Y G A E M V F S S K D S T I T
Baker's Yeast Sacchar. cerevisiae P40352 1085 124509 N698 D P D L S H L N Y L R M D G T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.2 83.3 N.A. N.A. 70.1 N.A. 44.6 N.A. N.A. N.A. N.A. 20 31.4 20.6 36.4
Protein Similarity: 100 99.4 97.9 89.1 N.A. N.A. 76.4 N.A. 52.2 N.A. N.A. N.A. N.A. 35.7 43.8 35.7 45.8
P-Site Identity: 100 100 80 6.6 N.A. N.A. 0 N.A. 0 N.A. N.A. N.A. N.A. 0 6.6 13.3 0
P-Site Similarity: 100 100 86.6 6.6 N.A. N.A. 26.6 N.A. 6.6 N.A. N.A. N.A. N.A. 6.6 26.6 53.3 13.3
Percent
Protein Identity: 29.4 N.A. N.A. 23.5 28.4 N.A.
Protein Similarity: 44.9 N.A. N.A. 38.2 43.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 0 N.A.
P-Site Similarity: 20 N.A. N.A. 33.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 31 8 16 0 16 8 8 8 0 0 8 8 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 8 0 16 0 8 0 0 8 16 8 16 31 8 8 8 % D
% Glu: 0 24 8 8 8 0 0 0 0 8 0 0 16 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % F
% Gly: 0 24 8 8 8 0 8 8 0 16 0 8 8 8 8 % G
% His: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % H
% Ile: 8 0 8 0 0 8 0 8 0 0 8 0 0 16 8 % I
% Lys: 8 8 0 0 16 0 8 0 8 16 16 8 0 0 24 % K
% Leu: 0 8 0 16 0 16 16 24 8 8 8 0 8 24 8 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 16 0 0 0 % M
% Asn: 8 8 0 24 0 8 8 8 24 0 0 16 0 0 0 % N
% Pro: 0 16 0 0 0 0 8 0 0 0 0 0 24 0 16 % P
% Gln: 0 0 8 16 0 0 8 0 0 8 0 8 0 0 0 % Q
% Arg: 0 0 0 8 0 0 0 0 8 16 16 0 16 8 0 % R
% Ser: 8 0 8 8 8 0 8 31 8 16 24 8 0 8 8 % S
% Thr: 8 0 8 16 16 8 24 0 16 0 8 0 16 16 16 % T
% Val: 16 8 24 0 16 47 0 0 0 0 0 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _