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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC6
All Species:
15.15
Human Site:
Y1250
Identified Species:
27.78
UniProt:
Q03468
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03468
NP_000115.1
1493
168416
Y1250
K
E
Q
S
N
D
D
Y
V
L
E
K
L
F
K
Chimpanzee
Pan troglodytes
XP_507781
1491
168031
Y1248
K
E
Q
S
N
D
D
Y
V
L
E
K
L
F
K
Rhesus Macaque
Macaca mulatta
XP_001107536
1496
168876
Y1253
K
E
Q
S
N
D
D
Y
V
L
E
K
L
F
K
Dog
Lupus familis
XP_534944
1486
168108
Y1243
S
E
Q
S
N
D
D
Y
V
L
E
K
L
F
K
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
NP_001100766
1325
148468
R1103
K
Q
K
A
K
N
S
R
H
H
R
D
A
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508174
968
109820
E746
N
T
N
G
L
S
G
E
N
S
K
Q
T
D
L
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24368
1027
118855
F805
T
A
W
T
K
R
D
F
N
Q
F
I
K
A
N
Honey Bee
Apis mellifera
XP_001120586
932
107557
K710
N
N
V
D
Q
D
I
K
I
Y
K
N
N
L
T
Nematode Worm
Caenorhab. elegans
P41877
1009
116656
E787
A
R
P
L
T
D
K
E
Q
E
E
K
A
E
L
Sea Urchin
Strong. purpuratus
XP_001193315
953
107227
Q731
L
Q
H
D
N
I
M
Q
S
S
N
P
D
F
V
Poplar Tree
Populus trichocarpa
XP_002307656
1206
134941
I983
S
L
F
D
A
N
G
I
H
S
A
V
N
H
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWY3
1057
122611
K835
T
T
E
E
V
E
E
K
E
G
L
L
E
E
G
Baker's Yeast
Sacchar. cerevisiae
P40352
1085
124509
S863
F
E
Q
L
V
N
L
S
G
V
S
K
L
E
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.2
83.3
N.A.
N.A.
70.1
N.A.
44.6
N.A.
N.A.
N.A.
N.A.
20
31.4
20.6
36.4
Protein Similarity:
100
99.4
97.9
89.1
N.A.
N.A.
76.4
N.A.
52.2
N.A.
N.A.
N.A.
N.A.
35.7
43.8
35.7
45.8
P-Site Identity:
100
100
100
93.3
N.A.
N.A.
6.6
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
6.6
20
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
N.A.
33.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
20
20
20
20
Percent
Protein Identity:
29.4
N.A.
N.A.
23.5
28.4
N.A.
Protein Similarity:
44.9
N.A.
N.A.
38.2
43.9
N.A.
P-Site Identity:
0
N.A.
N.A.
0
26.6
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
8
0
0
0
0
0
8
0
16
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
24
0
47
39
0
0
0
0
8
8
8
8
% D
% Glu:
0
39
8
8
0
8
8
16
8
8
39
0
8
24
0
% E
% Phe:
8
0
8
0
0
0
0
8
0
0
8
0
0
39
8
% F
% Gly:
0
0
0
8
0
0
16
0
8
8
0
0
0
0
8
% G
% His:
0
0
8
0
0
0
0
0
16
8
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
8
8
8
8
0
0
8
0
0
0
% I
% Lys:
31
0
8
0
16
0
8
16
0
0
16
47
8
8
31
% K
% Leu:
8
8
0
16
8
0
8
0
0
31
8
8
39
8
16
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
16
8
8
0
39
24
0
0
16
0
8
8
16
0
8
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
16
39
0
8
0
0
8
8
8
0
8
0
0
0
% Q
% Arg:
0
8
0
0
0
8
0
8
0
0
8
0
0
0
0
% R
% Ser:
16
0
0
31
0
8
8
8
8
24
8
0
0
0
8
% S
% Thr:
16
16
0
8
8
0
0
0
0
0
0
0
8
0
8
% T
% Val:
0
0
8
0
16
0
0
0
31
8
0
8
0
0
8
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
31
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _