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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC6
All Species:
14.24
Human Site:
Y741
Identified Species:
26.11
UniProt:
Q03468
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03468
NP_000115.1
1493
168416
Y741
L
R
D
T
I
N
P
Y
L
L
R
R
M
K
S
Chimpanzee
Pan troglodytes
XP_507781
1491
168031
Y739
L
R
D
T
I
N
P
Y
L
L
R
R
M
K
S
Rhesus Macaque
Macaca mulatta
XP_001107536
1496
168876
Y744
L
R
D
T
I
N
P
Y
L
L
R
R
M
K
S
Dog
Lupus familis
XP_534944
1486
168108
Y737
L
R
D
T
I
N
P
Y
L
L
R
R
M
K
S
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
NP_001100766
1325
148468
M617
Q
F
S
V
P
I
T
M
G
G
Y
S
N
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508174
968
109820
S260
C
Q
G
I
L
I
T
S
Y
S
Y
I
R
L
M
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24368
1027
118855
N318
E
D
F
D
E
W
F
N
T
N
T
C
L
G
D
Honey Bee
Apis mellifera
XP_001120586
932
107557
H224
G
N
L
E
Y
L
I
H
S
L
K
S
G
G
I
Nematode Worm
Caenorhab. elegans
P41877
1009
116656
A301
N
N
L
H
E
L
W
A
L
L
N
F
L
L
P
Sea Urchin
Strong. purpuratus
XP_001193315
953
107227
L245
D
V
K
Q
A
L
Q
L
P
S
K
N
E
Q
V
Poplar Tree
Populus trichocarpa
XP_002307656
1206
134941
E496
Q
S
Y
E
S
D
C
E
T
E
D
S
L
D
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWY3
1057
122611
L349
L
L
I
T
G
T
P
L
Q
N
N
L
H
E
L
Baker's Yeast
Sacchar. cerevisiae
P40352
1085
124509
L377
P
P
L
R
T
V
I
L
H
S
M
G
S
G
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.2
83.3
N.A.
N.A.
70.1
N.A.
44.6
N.A.
N.A.
N.A.
N.A.
20
31.4
20.6
36.4
Protein Similarity:
100
99.4
97.9
89.1
N.A.
N.A.
76.4
N.A.
52.2
N.A.
N.A.
N.A.
N.A.
35.7
43.8
35.7
45.8
P-Site Identity:
100
100
100
100
N.A.
N.A.
6.6
N.A.
0
N.A.
N.A.
N.A.
N.A.
0
6.6
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
N.A.
6.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
6.6
20
20
13.3
Percent
Protein Identity:
29.4
N.A.
N.A.
23.5
28.4
N.A.
Protein Similarity:
44.9
N.A.
N.A.
38.2
43.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
20
N.A.
N.A.
26.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
0
0
0
0
0
8
0
% A
% Cys:
8
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% C
% Asp:
8
8
31
8
0
8
0
0
0
0
8
0
0
8
8
% D
% Glu:
8
0
0
16
16
0
0
8
0
8
0
0
8
8
0
% E
% Phe:
0
8
8
0
0
0
8
0
0
0
0
8
0
0
0
% F
% Gly:
8
0
8
0
8
0
0
0
8
8
0
8
8
24
0
% G
% His:
0
0
0
8
0
0
0
8
8
0
0
0
8
0
0
% H
% Ile:
0
0
8
8
31
16
16
0
0
0
0
8
0
0
8
% I
% Lys:
0
0
8
0
0
0
0
0
0
0
16
0
0
31
0
% K
% Leu:
39
8
24
0
8
24
0
24
39
47
0
8
24
16
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
8
0
31
0
16
% M
% Asn:
8
16
0
0
0
31
0
8
0
16
16
8
8
0
0
% N
% Pro:
8
8
0
0
8
0
39
0
8
0
0
0
0
0
8
% P
% Gln:
16
8
0
8
0
0
8
0
8
0
0
0
0
8
0
% Q
% Arg:
0
31
0
8
0
0
0
0
0
0
31
31
8
0
0
% R
% Ser:
0
8
8
0
8
0
0
8
8
24
0
24
8
0
47
% S
% Thr:
0
0
0
39
8
8
16
0
16
0
8
0
0
0
0
% T
% Val:
0
8
0
8
0
8
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
0
31
8
0
16
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _