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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC6 All Species: 14.24
Human Site: Y741 Identified Species: 26.11
UniProt: Q03468 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03468 NP_000115.1 1493 168416 Y741 L R D T I N P Y L L R R M K S
Chimpanzee Pan troglodytes XP_507781 1491 168031 Y739 L R D T I N P Y L L R R M K S
Rhesus Macaque Macaca mulatta XP_001107536 1496 168876 Y744 L R D T I N P Y L L R R M K S
Dog Lupus familis XP_534944 1486 168108 Y737 L R D T I N P Y L L R R M K S
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus NP_001100766 1325 148468 M617 Q F S V P I T M G G Y S N A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508174 968 109820 S260 C Q G I L I T S Y S Y I R L M
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24368 1027 118855 N318 E D F D E W F N T N T C L G D
Honey Bee Apis mellifera XP_001120586 932 107557 H224 G N L E Y L I H S L K S G G I
Nematode Worm Caenorhab. elegans P41877 1009 116656 A301 N N L H E L W A L L N F L L P
Sea Urchin Strong. purpuratus XP_001193315 953 107227 L245 D V K Q A L Q L P S K N E Q V
Poplar Tree Populus trichocarpa XP_002307656 1206 134941 E496 Q S Y E S D C E T E D S L D S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWY3 1057 122611 L349 L L I T G T P L Q N N L H E L
Baker's Yeast Sacchar. cerevisiae P40352 1085 124509 L377 P P L R T V I L H S M G S G M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.2 83.3 N.A. N.A. 70.1 N.A. 44.6 N.A. N.A. N.A. N.A. 20 31.4 20.6 36.4
Protein Similarity: 100 99.4 97.9 89.1 N.A. N.A. 76.4 N.A. 52.2 N.A. N.A. N.A. N.A. 35.7 43.8 35.7 45.8
P-Site Identity: 100 100 100 100 N.A. N.A. 6.6 N.A. 0 N.A. N.A. N.A. N.A. 0 6.6 13.3 0
P-Site Similarity: 100 100 100 100 N.A. N.A. 6.6 N.A. 13.3 N.A. N.A. N.A. N.A. 6.6 20 20 13.3
Percent
Protein Identity: 29.4 N.A. N.A. 23.5 28.4 N.A.
Protein Similarity: 44.9 N.A. N.A. 38.2 43.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 20 0 N.A.
P-Site Similarity: 20 N.A. N.A. 26.6 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 8 0 0 0 0 0 8 0 % A
% Cys: 8 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % C
% Asp: 8 8 31 8 0 8 0 0 0 0 8 0 0 8 8 % D
% Glu: 8 0 0 16 16 0 0 8 0 8 0 0 8 8 0 % E
% Phe: 0 8 8 0 0 0 8 0 0 0 0 8 0 0 0 % F
% Gly: 8 0 8 0 8 0 0 0 8 8 0 8 8 24 0 % G
% His: 0 0 0 8 0 0 0 8 8 0 0 0 8 0 0 % H
% Ile: 0 0 8 8 31 16 16 0 0 0 0 8 0 0 8 % I
% Lys: 0 0 8 0 0 0 0 0 0 0 16 0 0 31 0 % K
% Leu: 39 8 24 0 8 24 0 24 39 47 0 8 24 16 8 % L
% Met: 0 0 0 0 0 0 0 8 0 0 8 0 31 0 16 % M
% Asn: 8 16 0 0 0 31 0 8 0 16 16 8 8 0 0 % N
% Pro: 8 8 0 0 8 0 39 0 8 0 0 0 0 0 8 % P
% Gln: 16 8 0 8 0 0 8 0 8 0 0 0 0 8 0 % Q
% Arg: 0 31 0 8 0 0 0 0 0 0 31 31 8 0 0 % R
% Ser: 0 8 8 0 8 0 0 8 8 24 0 24 8 0 47 % S
% Thr: 0 0 0 39 8 8 16 0 16 0 8 0 0 0 0 % T
% Val: 0 8 0 8 0 8 0 0 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 31 8 0 16 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _