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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RELA All Species: 9.7
Human Site: S353 Identified Species: 21.33
UniProt: Q04206 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04206 NP_001138610.1 551 60219 S353 P Q P Y P F T S S L S T I N Y
Chimpanzee Pan troglodytes XP_001170057 551 60215 S353 P Q P Y P F T S S L S T I N Y
Rhesus Macaque Macaca mulatta XP_001113258 543 59608 S353 Q P Y P F T S S L S T I N Y D
Dog Lupus familis XP_540850 542 59248 P353 P Q S Y P F T P S L S T I N F
Cat Felis silvestris
Mouse Mus musculus Q04207 549 60193 A353 P Q P Y T F P A S L S T I N F
Rat Rattus norvegicus NP_954888 550 60249 T353 P Q P Y A F S T S L S T I N F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506224 261 29575 V101 A V R L C F Q V T V Q D S A G
Chicken Gallus gallus P98152 558 60053 P358 P P S M V G A P P A P L F P L
Frog Xenopus laevis Q04865 527 59040 V353 S I P V P N P V V S C L P F S
Zebra Danio Brachydanio rerio NP_001001839 455 51088 H295 L P S D P D E H R L M E K R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15330 999 111533 F389 E I P S E M E F N H E E S Q Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 97.6 91.1 N.A. 88.9 90.3 N.A. 41.3 51.9 52.4 48.6 N.A. 26.5 N.A. N.A. N.A.
Protein Similarity: 100 100 98 93.6 N.A. 92.7 93.6 N.A. 44 62.9 65.1 61.5 N.A. 36.2 N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 80 N.A. 73.3 73.3 N.A. 6.6 6.6 13.3 13.3 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 20 86.6 N.A. 86.6 93.3 N.A. 20 6.6 13.3 13.3 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 10 0 10 10 0 10 0 0 0 10 0 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 0 0 0 10 0 10 0 0 0 0 0 10 0 0 10 % D
% Glu: 10 0 0 0 10 0 19 0 0 0 10 19 0 0 0 % E
% Phe: 0 0 0 0 10 55 0 10 0 0 0 0 10 10 28 % F
% Gly: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 10 0 10 0 0 0 0 0 % H
% Ile: 0 19 0 0 0 0 0 0 0 0 0 10 46 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % K
% Leu: 10 0 0 10 0 0 0 0 10 55 0 19 0 0 10 % L
% Met: 0 0 0 10 0 10 0 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 0 10 0 0 0 10 46 0 % N
% Pro: 55 28 55 10 46 0 19 19 10 0 10 0 10 10 0 % P
% Gln: 10 46 0 0 0 0 10 0 0 0 10 0 0 10 10 % Q
% Arg: 0 0 10 0 0 0 0 0 10 0 0 0 0 10 0 % R
% Ser: 10 0 28 10 0 0 19 28 46 19 46 0 19 0 10 % S
% Thr: 0 0 0 0 10 10 28 10 10 0 10 46 0 0 0 % T
% Val: 0 10 0 10 10 0 0 19 10 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 46 0 0 0 0 0 0 0 0 0 10 19 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _