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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATP7A All Species: 18.18
Human Site: T1443 Identified Species: 36.36
UniProt: Q04656 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04656 NP_000043.3 1500 163374 T1443 V H V G I D D T S R N S P K L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001103242 1333 143814 R1277 V H I G M D D R R R D S P R A
Dog Lupus familis XP_549096 1499 164030 T1442 V H V G I D D T S R N S P K L
Cat Felis silvestris
Mouse Mus musculus Q64430 1491 161891 T1434 V H V G I D D T S R N S P R L
Rat Rattus norvegicus P70705 1492 162074 T1435 V H V G I D D T S R N S P R L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507266 1609 174606 A1552 V H V G I D D A S R D A P N L
Chicken Gallus gallus XP_420307 1494 162045 T1437 V H I G I D E T G T G T R K L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001036185 1482 159963 L1426 V H I G M G E L R R P S P K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572756 1254 136064 S1198 G R M P F K R S S T S L I S R
Honey Bee Apis mellifera XP_395837 1274 139224 V1218 H R G L D D S V L P I M H R S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SH30 995 108318 A939 L M G I P I A A G V L F P G T
Baker's Yeast Sacchar. cerevisiae P38995 1004 109810 L948 V S V V L S S L M L K K W T P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 51 92.4 N.A. 89.1 88.7 N.A. 75.1 73.1 N.A. 65.4 N.A. 41.4 44.1 N.A. N.A.
Protein Similarity: 100 N.A. 67.2 96 N.A. 94.4 94 N.A. 83.5 83.9 N.A. 77.8 N.A. 56.3 58.5 N.A. N.A.
P-Site Identity: 100 N.A. 53.3 100 N.A. 93.3 93.3 N.A. 73.3 53.3 N.A. 53.3 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 N.A. 80 100 N.A. 100 100 N.A. 86.6 73.3 N.A. 73.3 N.A. 26.6 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 31.3 28.2 N.A.
Protein Similarity: N.A. N.A. N.A. 45.1 44.7 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 9 17 0 0 0 9 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 9 67 50 0 0 0 17 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 9 0 0 0 % F
% Gly: 9 0 17 67 0 9 0 0 17 0 9 0 0 9 0 % G
% His: 9 67 0 0 0 0 0 0 0 0 0 0 9 0 0 % H
% Ile: 0 0 25 9 50 9 0 0 0 0 9 0 9 0 0 % I
% Lys: 0 0 0 0 0 9 0 0 0 0 9 9 0 34 0 % K
% Leu: 9 0 0 9 9 0 0 17 9 9 9 9 0 0 59 % L
% Met: 0 9 9 0 17 0 0 0 9 0 0 9 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 34 0 0 9 0 % N
% Pro: 0 0 0 9 9 0 0 0 0 9 9 0 67 0 9 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 17 0 0 0 0 9 9 17 59 0 0 9 34 9 % R
% Ser: 0 9 0 0 0 9 17 9 50 0 9 50 0 9 9 % S
% Thr: 0 0 0 0 0 0 0 42 0 17 0 9 0 9 9 % T
% Val: 75 0 50 9 0 0 0 9 0 9 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _