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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH2 All Species: 18.48
Human Site: S2115 Identified Species: 33.89
UniProt: Q04721 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04721 NP_077719.2 2471 265405 S2115 A K S T M P T S L P N L A K E
Chimpanzee Pan troglodytes XP_513697 2179 233874 K1829 T S L P N L A K E A K D A K G
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 S2115 A K N T M P T S L P N L A K E
Dog Lupus familis XP_540266 2471 265327 S2115 T K S T M P T S L P N L A K E
Cat Felis silvestris
Mouse Mus musculus O35516 2470 265309 S2113 T K S T M P T S L P N L A K E
Rat Rattus norvegicus Q9QW30 2471 265351 S2115 T K S T M P T S L P N L A K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 S2111 S A K G A V P S S L P N L A R
Chicken Gallus gallus XP_001233596 2467 266140 K2115 L K H A S L S K K S R K P N A
Frog Xenopus laevis P21783 2524 275106 K2160 K A R K P S I K G N G C K E A
Zebra Danio Brachydanio rerio P46530 2437 262289 R2086 D H L D Q L P R D I A H E R M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 G2180 V I S A G N G G N N G N G N A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 E1079 L I V H E A K E C I A A G A D
Sea Urchin Strong. purpuratus P10079 1064 112055 S714 I N I D E C A S A P C Q N G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88 99 95.3 N.A. 91.7 92.1 N.A. 78.3 75.8 53.6 53.7 N.A. 42.4 N.A. 21.7 23
Protein Similarity: 100 88.1 99.4 97.5 N.A. 95.3 95.7 N.A. 86.5 85.1 68.2 68.7 N.A. 57.2 N.A. 33.9 30.3
P-Site Identity: 100 13.3 93.3 93.3 N.A. 93.3 93.3 N.A. 6.6 6.6 0 0 N.A. 6.6 N.A. 0 13.3
P-Site Similarity: 100 13.3 100 93.3 N.A. 93.3 93.3 N.A. 13.3 13.3 6.6 6.6 N.A. 6.6 N.A. 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 16 0 16 8 8 16 0 8 8 16 8 47 16 24 % A
% Cys: 0 0 0 0 0 8 0 0 8 0 8 8 0 0 0 % C
% Asp: 8 0 0 16 0 0 0 0 8 0 0 8 0 0 8 % D
% Glu: 0 0 0 0 16 0 0 8 8 0 0 0 8 8 39 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 8 0 8 8 8 0 16 0 16 8 16 % G
% His: 0 8 8 8 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 8 16 8 0 0 0 8 0 0 16 0 0 0 0 0 % I
% Lys: 8 47 8 8 0 0 8 24 8 0 8 8 8 47 0 % K
% Leu: 16 0 16 0 0 24 0 0 39 8 0 39 8 0 0 % L
% Met: 0 0 0 0 39 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 8 8 0 8 8 0 0 8 16 39 16 8 16 0 % N
% Pro: 0 0 0 8 8 39 16 0 0 47 8 0 8 0 0 % P
% Gln: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 0 8 0 0 0 0 8 0 0 8 0 0 8 8 % R
% Ser: 8 8 39 0 8 8 8 54 8 8 0 0 0 0 0 % S
% Thr: 31 0 0 39 0 0 39 0 0 0 0 0 0 0 0 % T
% Val: 8 0 8 0 0 8 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _