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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
18.48
Human Site:
S2115
Identified Species:
33.89
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2115
A
K
S
T
M
P
T
S
L
P
N
L
A
K
E
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
K1829
T
S
L
P
N
L
A
K
E
A
K
D
A
K
G
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2115
A
K
N
T
M
P
T
S
L
P
N
L
A
K
E
Dog
Lupus familis
XP_540266
2471
265327
S2115
T
K
S
T
M
P
T
S
L
P
N
L
A
K
E
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S2113
T
K
S
T
M
P
T
S
L
P
N
L
A
K
E
Rat
Rattus norvegicus
Q9QW30
2471
265351
S2115
T
K
S
T
M
P
T
S
L
P
N
L
A
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S2111
S
A
K
G
A
V
P
S
S
L
P
N
L
A
R
Chicken
Gallus gallus
XP_001233596
2467
266140
K2115
L
K
H
A
S
L
S
K
K
S
R
K
P
N
A
Frog
Xenopus laevis
P21783
2524
275106
K2160
K
A
R
K
P
S
I
K
G
N
G
C
K
E
A
Zebra Danio
Brachydanio rerio
P46530
2437
262289
R2086
D
H
L
D
Q
L
P
R
D
I
A
H
E
R
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
G2180
V
I
S
A
G
N
G
G
N
N
G
N
G
N
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
E1079
L
I
V
H
E
A
K
E
C
I
A
A
G
A
D
Sea Urchin
Strong. purpuratus
P10079
1064
112055
S714
I
N
I
D
E
C
A
S
A
P
C
Q
N
G
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
13.3
93.3
93.3
N.A.
93.3
93.3
N.A.
6.6
6.6
0
0
N.A.
6.6
N.A.
0
13.3
P-Site Similarity:
100
13.3
100
93.3
N.A.
93.3
93.3
N.A.
13.3
13.3
6.6
6.6
N.A.
6.6
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
16
0
16
8
8
16
0
8
8
16
8
47
16
24
% A
% Cys:
0
0
0
0
0
8
0
0
8
0
8
8
0
0
0
% C
% Asp:
8
0
0
16
0
0
0
0
8
0
0
8
0
0
8
% D
% Glu:
0
0
0
0
16
0
0
8
8
0
0
0
8
8
39
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
8
0
8
8
8
0
16
0
16
8
16
% G
% His:
0
8
8
8
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
16
8
0
0
0
8
0
0
16
0
0
0
0
0
% I
% Lys:
8
47
8
8
0
0
8
24
8
0
8
8
8
47
0
% K
% Leu:
16
0
16
0
0
24
0
0
39
8
0
39
8
0
0
% L
% Met:
0
0
0
0
39
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
8
8
0
8
8
0
0
8
16
39
16
8
16
0
% N
% Pro:
0
0
0
8
8
39
16
0
0
47
8
0
8
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
8
0
0
8
0
0
8
8
% R
% Ser:
8
8
39
0
8
8
8
54
8
8
0
0
0
0
0
% S
% Thr:
31
0
0
39
0
0
39
0
0
0
0
0
0
0
0
% T
% Val:
8
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _