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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
22.73
Human Site:
S2144
Identified Species:
41.67
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2144
E
K
V
Q
L
S
E
S
S
V
T
L
S
P
V
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
P1858
E
S
S
V
T
L
S
P
V
D
S
L
E
S
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2144
E
K
V
Q
L
S
E
S
S
V
T
L
S
P
V
Dog
Lupus familis
XP_540266
2471
265327
S2144
D
K
G
Q
L
S
E
S
S
V
T
L
S
P
V
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S2142
E
K
V
Q
L
S
E
S
S
V
T
L
S
P
V
Rat
Rattus norvegicus
Q9QW30
2471
265351
S2144
E
K
V
Q
L
S
E
S
S
V
T
L
S
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S2140
L
G
E
K
G
Q
L
S
E
S
S
V
T
L
S
Chicken
Gallus gallus
XP_001233596
2467
266140
E2144
R
R
K
K
S
L
S
E
S
K
G
Q
F
S
E
Frog
Xenopus laevis
P21783
2524
275106
S2189
T
T
L
L
D
S
G
S
S
G
V
L
S
P
V
Zebra Danio
Brachydanio rerio
P46530
2437
262289
S2115
R
S
P
P
L
P
L
S
P
P
L
C
C
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
G2209
K
K
A
K
L
I
E
G
S
P
D
N
G
L
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
R1108
A
V
L
A
R
R
R
R
L
V
A
Y
L
M
K
Sea Urchin
Strong. purpuratus
P10079
1064
112055
C743
P
G
Y
T
G
D
N
C
E
T
E
I
D
E
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
13.3
100
86.6
N.A.
100
100
N.A.
6.6
6.6
46.6
20
N.A.
26.6
N.A.
6.6
0
P-Site Similarity:
100
20
100
93.3
N.A.
100
100
N.A.
33.3
20
53.3
20
N.A.
40
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
8
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
8
8
0
8
% C
% Asp:
8
0
0
0
8
8
0
0
0
8
8
0
8
0
8
% D
% Glu:
39
0
8
0
0
0
47
8
16
0
8
0
8
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
16
8
0
16
0
8
8
0
8
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% I
% Lys:
8
47
8
24
0
0
0
0
0
8
0
0
0
0
8
% K
% Leu:
8
0
16
8
54
16
16
0
8
0
8
54
8
16
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
8
% N
% Pro:
8
0
8
8
0
8
0
8
8
16
0
0
0
54
8
% P
% Gln:
0
0
0
39
0
8
0
0
0
0
0
8
0
0
0
% Q
% Arg:
16
8
0
0
8
8
8
8
0
0
0
0
0
0
0
% R
% Ser:
0
16
8
0
8
47
16
62
62
8
16
0
47
16
8
% S
% Thr:
8
8
0
8
8
0
0
0
0
8
39
0
8
0
0
% T
% Val:
0
8
31
8
0
0
0
0
8
47
8
8
0
0
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _