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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH2 All Species: 5.76
Human Site: S2242 Identified Species: 10.56
UniProt: Q04721 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04721 NP_077719.2 2471 265405 S2242 S G S A G S L S R L H P V P V
Chimpanzee Pan troglodytes XP_513697 2179 233874 P1956 L S R L H P V P V P A D W M N
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 S2242 S G S A G S L S R L H P V P V
Dog Lupus familis XP_540266 2471 265327 G2242 N G S A G S L G R L H P V T V
Cat Felis silvestris
Mouse Mus musculus O35516 2470 265309 G2240 S S S A G S L G R L H P V P V
Rat Rattus norvegicus Q9QW30 2471 265351 R2242 G S A G S L G R L H S V P V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 L2238 G G G S L G R L H P V N V P A
Chicken Gallus gallus XP_001233596 2467 266140 G2242 T P P S S G L G R L R P A N V
Frog Xenopus laevis P21783 2524 275106 T2287 S N G S M H F T V G G A P T M
Zebra Danio Brachydanio rerio P46530 2437 262289 L2213 Q Q S P P I S L N Q L Q G L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 N2307 D T S S M Y S N A M A A P L A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 K1206 R K D S E K Y K G R T A L H Y
Sea Urchin Strong. purpuratus P10079 1064 112055 V841 G G I C V D G V N G F V C Q C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88 99 95.3 N.A. 91.7 92.1 N.A. 78.3 75.8 53.6 53.7 N.A. 42.4 N.A. 21.7 23
Protein Similarity: 100 88.1 99.4 97.5 N.A. 95.3 95.7 N.A. 86.5 85.1 68.2 68.7 N.A. 57.2 N.A. 33.9 30.3
P-Site Identity: 100 0 100 80 N.A. 86.6 0 N.A. 20 33.3 6.6 6.6 N.A. 6.6 N.A. 0 6.6
P-Site Similarity: 100 6.6 100 86.6 N.A. 86.6 6.6 N.A. 26.6 46.6 26.6 6.6 N.A. 26.6 N.A. 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 31 0 0 0 0 8 0 16 24 8 0 24 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 8 % C
% Asp: 8 0 8 0 0 8 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % F
% Gly: 24 39 16 8 31 16 16 24 8 16 8 0 8 0 0 % G
% His: 0 0 0 0 8 8 0 0 8 8 31 0 0 8 0 % H
% Ile: 0 0 8 0 0 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 0 0 0 8 0 8 0 0 0 0 0 0 0 % K
% Leu: 8 0 0 8 8 8 39 16 8 39 8 0 8 16 0 % L
% Met: 0 0 0 0 16 0 0 0 0 8 0 0 0 8 8 % M
% Asn: 8 8 0 0 0 0 0 8 16 0 0 8 0 8 8 % N
% Pro: 0 8 8 8 8 8 0 8 0 16 0 39 24 31 8 % P
% Gln: 8 8 0 0 0 0 0 0 0 8 0 8 0 8 0 % Q
% Arg: 8 0 8 0 0 0 8 8 39 8 8 0 0 0 0 % R
% Ser: 31 24 47 39 16 31 16 16 0 0 8 0 0 0 0 % S
% Thr: 8 8 0 0 0 0 0 8 0 0 8 0 0 16 0 % T
% Val: 0 0 0 0 8 0 8 8 16 0 8 16 39 8 39 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _