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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
23.03
Human Site:
S2379
Identified Species:
42.22
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2379
A
Y
H
P
F
P
A
S
V
G
K
Y
P
T
P
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
V2088
Y
H
P
F
P
A
S
V
G
K
Y
P
T
P
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2379
A
Y
H
P
F
P
A
S
V
G
K
Y
P
T
P
Dog
Lupus familis
XP_540266
2471
265327
S2379
A
Y
H
P
F
P
A
S
V
G
K
Y
P
T
P
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S2378
T
Y
H
P
F
P
A
S
V
G
K
Y
P
T
P
Rat
Rattus norvegicus
Q9QW30
2471
265351
S2379
T
Y
H
P
F
P
A
S
V
G
K
Y
P
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S2374
A
Y
H
P
F
P
S
S
V
G
K
Y
P
T
P
Chicken
Gallus gallus
XP_001233596
2467
266140
Y2374
P
Q
T
I
L
P
A
Y
H
Q
F
Q
S
S
M
Frog
Xenopus laevis
P21783
2524
275106
N2421
L
Q
Q
M
S
S
N
N
I
H
S
V
M
P
Q
Zebra Danio
Brachydanio rerio
P46530
2437
262289
I2346
S
S
S
G
H
A
P
I
Q
T
I
L
P
Q
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
G2594
S
P
D
S
F
H
S
G
Q
M
N
P
P
S
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
N1338
S
K
K
E
S
A
S
N
S
R
D
S
T
H
L
Sea Urchin
Strong. purpuratus
P10079
1064
112055
R973
D
Y
M
T
Y
N
E
R
A
L
G
Y
A
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
93.3
13.3
0
6.6
N.A.
13.3
N.A.
0
20
P-Site Similarity:
100
20
100
100
N.A.
93.3
93.3
N.A.
100
20
13.3
13.3
N.A.
33.3
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
0
0
0
0
24
47
0
8
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
0
0
0
0
0
8
0
0
0
8
% D
% Glu:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
54
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
8
8
47
8
0
0
0
0
% G
% His:
0
8
47
0
8
8
0
0
8
8
0
0
0
8
0
% H
% Ile:
0
0
0
8
0
0
0
8
8
0
8
0
0
0
8
% I
% Lys:
0
8
8
0
0
0
0
0
0
8
47
0
0
0
0
% K
% Leu:
8
0
0
0
8
0
0
0
0
8
0
8
0
0
8
% L
% Met:
0
0
8
8
0
0
0
0
0
8
0
0
8
0
8
% M
% Asn:
0
0
0
0
0
8
8
16
0
0
8
0
0
0
0
% N
% Pro:
8
8
8
47
8
54
8
0
0
0
0
16
62
16
62
% P
% Gln:
0
16
8
0
0
0
0
0
16
8
0
8
0
8
8
% Q
% Arg:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% R
% Ser:
24
8
8
8
16
8
31
47
8
0
8
8
8
16
0
% S
% Thr:
16
0
8
8
0
0
0
0
0
8
0
0
16
47
0
% T
% Val:
0
0
0
0
0
0
0
8
47
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
54
0
0
8
0
0
8
0
0
8
54
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _