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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH2 All Species: 26.67
Human Site: T1808 Identified Species: 48.89
UniProt: Q04721 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04721 NP_077719.2 2471 265405 T1808 R T P S L A L T P P Q A E Q E
Chimpanzee Pan troglodytes XP_513697 2179 233874 Y1595 A L H L A A R Y S R A D A A K
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 T1808 R T P S L A L T P P Q A E Q E
Dog Lupus familis XP_540266 2471 265327 T1808 R T P S L A L T P P Q A E Q E
Cat Felis silvestris
Mouse Mus musculus O35516 2470 265309 T1806 H T P S L A L T P P Q A E Q E
Rat Rattus norvegicus Q9QW30 2471 265351 T1808 R T P S L A L T P P Q A E Q E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 T1804 R A P S L A L T P P Q A E Q E
Chicken Gallus gallus XP_001233596 2467 266140 T1819 G S T S L A L T P P Q A D Q E
Frog Xenopus laevis P21783 2524 275106 P1858 I S S M A P T P P Q G E I E A
Zebra Danio Brachydanio rerio P46530 2437 262289 P1849 L N S M A P T P P Q G Q I E N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 H1887 A I M T P P A H Q D G G K H D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 V845 S A T N I G V V V Y L E V Q E
Sea Urchin Strong. purpuratus P10079 1064 112055 D480 T G V L C E T D I N E C A S M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88 99 95.3 N.A. 91.7 92.1 N.A. 78.3 75.8 53.6 53.7 N.A. 42.4 N.A. 21.7 23
Protein Similarity: 100 88.1 99.4 97.5 N.A. 95.3 95.7 N.A. 86.5 85.1 68.2 68.7 N.A. 57.2 N.A. 33.9 30.3
P-Site Identity: 100 6.6 100 100 N.A. 93.3 100 N.A. 93.3 73.3 6.6 6.6 N.A. 0 N.A. 13.3 0
P-Site Similarity: 100 13.3 100 100 N.A. 93.3 100 N.A. 93.3 86.6 20 13.3 N.A. 20 N.A. 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 16 0 0 24 62 8 0 0 0 8 54 16 8 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 0 8 0 8 8 0 8 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 8 16 47 16 62 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 8 0 0 0 8 0 0 0 0 24 8 0 0 0 % G
% His: 8 0 8 0 0 0 0 8 0 0 0 0 0 8 0 % H
% Ile: 8 8 0 0 8 0 0 0 8 0 0 0 16 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % K
% Leu: 8 8 0 16 54 0 54 0 0 0 8 0 0 0 0 % L
% Met: 0 0 8 16 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 8 0 8 0 0 0 0 0 8 0 0 0 0 8 % N
% Pro: 0 0 47 0 8 24 0 16 70 54 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 16 54 8 0 62 0 % Q
% Arg: 39 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % R
% Ser: 8 16 16 54 0 0 0 0 8 0 0 0 0 8 0 % S
% Thr: 8 39 16 8 0 0 24 54 0 0 0 0 0 0 0 % T
% Val: 0 0 8 0 0 0 8 8 8 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _