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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLE4
All Species:
33.03
Human Site:
S222
Identified Species:
66.06
UniProt:
Q04727
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04727
NP_008936.2
773
83755
S222
G
A
E
K
H
R
N
S
A
D
Y
S
S
E
S
Chimpanzee
Pan troglodytes
XP_001151633
774
83895
S223
G
A
E
K
H
R
N
S
T
D
Y
S
S
E
S
Rhesus Macaque
Macaca mulatta
XP_001103112
774
83994
S223
G
A
E
K
H
R
N
S
T
D
Y
S
S
E
S
Dog
Lupus familis
XP_533519
800
86502
S249
G
A
E
K
H
R
N
S
T
D
Y
S
S
D
S
Cat
Felis silvestris
Mouse
Mus musculus
Q62441
773
83769
S222
G
S
E
K
H
R
N
S
T
D
Y
S
S
E
S
Rat
Rattus norvegicus
Q07141
748
81316
S197
G
S
E
K
H
R
N
S
T
D
Y
S
S
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511846
774
83762
S223
A
A
E
K
H
R
N
S
T
D
Y
S
S
D
S
Chicken
Gallus gallus
NP_989568
773
83801
S222
T
A
E
K
H
R
N
S
T
D
Y
S
S
E
S
Frog
Xenopus laevis
O42478
772
83688
S223
A
A
E
K
H
R
N
S
T
D
Y
S
S
E
S
Zebra Danio
Brachydanio rerio
O13166
761
82441
G222
T
T
S
E
K
H
R
G
S
S
D
Y
S
L
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16371
730
80213
R201
G
P
A
A
A
E
E
R
L
R
N
S
V
S
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02482
612
65598
Q85
P
Q
L
S
Q
D
N
Q
A
N
C
L
A
A
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.6
95
N.A.
99.6
92.2
N.A.
98.3
99.3
97.5
80.3
N.A.
59.6
N.A.
40.2
N.A.
Protein Similarity:
100
99.7
99.6
95.5
N.A.
99.8
93.2
N.A.
98.8
99.3
98.1
87.4
N.A.
69.8
N.A.
52.9
N.A.
P-Site Identity:
100
93.3
93.3
86.6
N.A.
86.6
86.6
N.A.
80
86.6
86.6
6.6
N.A.
13.3
N.A.
13.3
N.A.
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
86.6
20
N.A.
13.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
59
9
9
9
0
0
0
17
0
0
0
9
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
0
0
75
9
0
0
17
9
% D
% Glu:
0
0
75
9
0
9
9
0
0
0
0
0
0
59
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
59
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
75
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
75
9
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
0
0
0
0
0
9
0
0
9
0
9
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
84
0
0
9
9
0
0
0
0
% N
% Pro:
9
9
0
0
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
9
0
0
9
0
0
9
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
75
9
9
0
9
0
0
0
0
0
% R
% Ser:
0
17
9
9
0
0
0
75
9
9
0
84
84
9
75
% S
% Thr:
17
9
0
0
0
0
0
0
67
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
75
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _