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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
YWHAH
All Species:
45.15
Human Site:
S139
Identified Species:
70.95
UniProt:
Q04917
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04917
NP_003396.1
246
28219
S139
R
Y
L
A
E
V
A
S
G
E
K
K
N
S
V
Chimpanzee
Pan troglodytes
XP_519163
321
36086
T213
R
Y
L
A
E
V
A
T
G
E
K
R
A
T
V
Rhesus Macaque
Macaca mulatta
XP_001111955
233
26714
V133
S
G
E
K
K
N
S
V
V
E
A
S
E
A
A
Dog
Lupus familis
XP_546936
343
38553
T235
R
Y
L
A
E
V
A
T
G
E
K
R
A
T
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQV8
246
28068
S136
R
Y
L
S
E
V
A
S
G
E
N
K
Q
T
T
Rat
Rattus norvegicus
P68511
246
28193
S139
R
Y
L
A
E
V
A
S
G
E
K
K
N
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505266
247
28347
A139
R
Y
L
A
E
V
A
A
G
E
K
K
N
S
V
Chicken
Gallus gallus
Q5F3W6
247
28212
T139
R
Y
L
A
E
V
A
T
G
E
K
R
A
T
V
Frog
Xenopus laevis
Q6PCG0
247
28255
T139
R
Y
L
A
E
V
A
T
G
E
K
R
A
T
V
Zebra Danio
Brachydanio rerio
Q6PC29
247
28216
T139
R
Y
L
A
E
V
A
T
G
E
K
R
A
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29310
248
28209
T137
R
Y
L
A
E
V
A
T
G
D
A
R
N
T
V
Honey Bee
Apis mellifera
XP_391841
247
28058
T136
R
Y
L
A
E
V
A
T
G
E
T
R
N
A
V
Nematode Worm
Caenorhab. elegans
Q20655
248
28049
S136
R
Y
L
A
E
V
A
S
G
D
D
R
N
S
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42644
255
28588
A139
R
Y
L
A
E
F
K
A
G
A
E
R
K
E
A
Baker's Yeast
Sacchar. cerevisiae
P34730
273
31043
S139
R
Y
L
A
E
F
S
S
G
D
A
R
E
K
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.9
88.6
60
N.A.
76.8
99.1
N.A.
89.4
86.2
87.8
86.2
N.A.
72.5
76.9
75.8
N.A.
Protein Similarity:
100
71.6
90.2
65
N.A.
86.9
99.5
N.A.
91.5
92.7
93.9
93.1
N.A.
85.8
87.8
86.6
N.A.
P-Site Identity:
100
73.3
6.6
73.3
N.A.
66.6
100
N.A.
93.3
73.3
73.3
73.3
N.A.
66.6
73.3
80
N.A.
P-Site Similarity:
100
93.3
26.6
93.3
N.A.
80
100
N.A.
100
93.3
93.3
93.3
N.A.
93.3
93.3
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60
56.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74.9
70.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
87
0
0
80
14
0
7
20
0
34
20
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
20
7
0
0
0
0
% D
% Glu:
0
0
7
0
94
0
0
0
0
74
7
0
14
7
0
% E
% Phe:
0
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
0
94
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
7
7
0
7
0
0
0
54
27
7
7
0
% K
% Leu:
0
0
94
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
0
0
7
0
40
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
94
0
0
0
0
0
0
0
0
0
0
67
0
0
0
% R
% Ser:
7
0
0
7
0
0
14
34
0
0
0
7
0
27
0
% S
% Thr:
0
0
0
0
0
0
0
47
0
0
7
0
0
40
7
% T
% Val:
0
0
0
0
0
80
0
7
7
0
0
0
0
0
74
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
94
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _