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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
YWHAH
All Species:
31.82
Human Site:
S65
Identified Species:
50
UniProt:
Q04917
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04917
NP_003396.1
246
28219
S65
S
S
W
R
V
I
S
S
I
E
Q
K
T
M
A
Chimpanzee
Pan troglodytes
XP_519163
321
36086
S139
S
S
W
R
V
I
S
S
I
E
Q
K
T
S
A
Rhesus Macaque
Macaca mulatta
XP_001111955
233
26714
A59
S
I
E
Q
K
T
M
A
D
G
N
E
K
K
L
Dog
Lupus familis
XP_546936
343
38553
S161
S
S
W
R
V
I
S
S
I
E
Q
K
T
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQV8
246
28068
R62
G
A
R
R
S
S
W
R
V
I
S
S
I
E
Q
Rat
Rattus norvegicus
P68511
246
28193
S65
S
S
W
R
V
I
S
S
I
E
Q
K
T
M
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505266
247
28347
S65
S
S
W
R
V
I
S
S
I
E
Q
K
T
M
A
Chicken
Gallus gallus
Q5F3W6
247
28212
S65
S
S
W
R
V
I
S
S
I
E
Q
K
T
S
A
Frog
Xenopus laevis
Q6PCG0
247
28255
S65
S
S
W
R
V
I
S
S
I
E
Q
K
T
S
A
Zebra Danio
Brachydanio rerio
Q6PC29
247
28216
S65
S
S
W
R
V
I
S
S
I
E
Q
K
T
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29310
248
28209
R63
G
A
R
R
S
S
W
R
V
I
S
S
I
E
Q
Honey Bee
Apis mellifera
XP_391841
247
28058
R62
G
A
R
R
S
S
W
R
V
I
S
S
I
E
Q
Nematode Worm
Caenorhab. elegans
Q20655
248
28049
R62
G
A
R
R
S
S
W
R
V
I
S
S
I
E
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42644
255
28588
I65
R
R
A
S
W
R
I
I
S
S
I
E
Q
K
E
Baker's Yeast
Sacchar. cerevisiae
P34730
273
31043
S65
R
A
S
W
R
I
V
S
S
I
E
Q
K
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.9
88.6
60
N.A.
76.8
99.1
N.A.
89.4
86.2
87.8
86.2
N.A.
72.5
76.9
75.8
N.A.
Protein Similarity:
100
71.6
90.2
65
N.A.
86.9
99.5
N.A.
91.5
92.7
93.9
93.1
N.A.
85.8
87.8
86.6
N.A.
P-Site Identity:
100
93.3
6.6
93.3
N.A.
6.6
100
N.A.
100
93.3
93.3
93.3
N.A.
6.6
6.6
6.6
N.A.
P-Site Similarity:
100
93.3
26.6
93.3
N.A.
20
100
N.A.
100
93.3
93.3
93.3
N.A.
20
20
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60
56.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74.9
70.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
34
7
0
0
0
0
7
0
0
0
0
0
0
54
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% D
% Glu:
0
0
7
0
0
0
0
0
0
54
7
14
0
34
14
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
27
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
60
7
7
54
34
7
0
27
0
0
% I
% Lys:
0
0
0
0
7
0
0
0
0
0
0
54
14
14
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
20
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
54
7
7
0
27
% Q
% Arg:
14
7
27
80
7
7
0
27
0
0
0
0
0
0
0
% R
% Ser:
60
54
7
7
27
27
54
60
14
7
27
27
0
34
0
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
0
54
0
0
% T
% Val:
0
0
0
0
54
0
7
0
27
0
0
0
0
0
0
% V
% Trp:
0
0
54
7
7
0
27
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _