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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: YWHAH All Species: 57.58
Human Site: Y184 Identified Species: 90.48
UniProt: Q04917 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04917 NP_003396.1 246 28219 Y184 L N F S V F Y Y E I Q N A P E
Chimpanzee Pan troglodytes XP_519163 321 36086 Y258 L N Y S V F Y Y E I Q N A P E
Rhesus Macaque Macaca mulatta XP_001111955 233 26714 E178 Y E I Q N A P E Q A C L L A K
Dog Lupus familis XP_546936 343 38553 Y280 L N Y S V F Y Y E I Q N A P E
Cat Felis silvestris
Mouse Mus musculus Q9CQV8 246 28068 Y181 L N F S V F Y Y E I L N S P E
Rat Rattus norvegicus P68511 246 28193 Y184 L N F S V F Y Y E I Q N A P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505266 247 28347 Y184 L N F S V F Y Y E I Q N A P E
Chicken Gallus gallus Q5F3W6 247 28212 Y184 L N Y S V F Y Y E I Q N A P E
Frog Xenopus laevis Q6PCG0 247 28255 Y184 L N Y S V F Y Y E I Q N A P E
Zebra Danio Brachydanio rerio Q6PC29 247 28216 Y184 L N Y S V F Y Y E I Q N A P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29310 248 28209 Y182 L N F S V F Y Y E I L N S P D
Honey Bee Apis mellifera XP_391841 247 28058 Y181 L N F S V F Y Y E I L N S P D
Nematode Worm Caenorhab. elegans Q20655 248 28049 Y181 L N F S V F F Y E I L N A P D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42644 255 28588 Y184 L N F S V F Y Y E I L N S P D
Baker's Yeast Sacchar. cerevisiae P34730 273 31043 Y184 L N F S V F Y Y E I Q N S P D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 66.9 88.6 60 N.A. 76.8 99.1 N.A. 89.4 86.2 87.8 86.2 N.A. 72.5 76.9 75.8 N.A.
Protein Similarity: 100 71.6 90.2 65 N.A. 86.9 99.5 N.A. 91.5 92.7 93.9 93.1 N.A. 85.8 87.8 86.6 N.A.
P-Site Identity: 100 93.3 0 93.3 N.A. 86.6 100 N.A. 100 93.3 93.3 93.3 N.A. 80 80 80 N.A.
P-Site Similarity: 100 100 13.3 100 N.A. 93.3 100 N.A. 100 100 100 100 N.A. 93.3 93.3 93.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 60 56.7 N.A.
Protein Similarity: N.A. N.A. N.A. 74.9 70.3 N.A.
P-Site Identity: N.A. N.A. N.A. 80 86.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 0 0 0 7 0 0 60 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 34 % D
% Glu: 0 7 0 0 0 0 0 7 94 0 0 0 0 0 60 % E
% Phe: 0 0 60 0 0 94 7 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 94 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % K
% Leu: 94 0 0 0 0 0 0 0 0 0 34 7 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 94 0 0 7 0 0 0 0 0 0 94 0 0 0 % N
% Pro: 0 0 0 0 0 0 7 0 0 0 0 0 0 94 0 % P
% Gln: 0 0 0 7 0 0 0 0 7 0 60 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 94 0 0 0 0 0 0 0 0 34 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 94 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 34 0 0 0 87 94 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _