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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ICA1
All Species:
30
Human Site:
S65
Identified Species:
55
UniProt:
Q05084
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05084
NP_001129492.1
483
54645
S65
A
K
L
E
L
F
H
S
I
Q
R
T
C
L
D
Chimpanzee
Pan troglodytes
XP_518971
483
54670
S65
A
K
L
E
L
F
H
S
I
Q
R
T
C
L
D
Rhesus Macaque
Macaca mulatta
XP_001086048
484
54745
S65
A
K
L
E
L
F
H
S
I
Q
R
T
C
L
D
Dog
Lupus familis
XP_850551
483
54711
S65
A
K
L
E
L
F
H
S
I
Q
R
T
C
L
D
Cat
Felis silvestris
Mouse
Mus musculus
P97411
478
54364
I65
K
L
E
L
F
H
S
I
Q
R
T
C
L
D
L
Rat
Rattus norvegicus
Q63054
480
54644
I65
K
L
E
L
F
H
S
I
Q
R
T
C
L
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508894
481
54258
K72
E
L
L
K
I
V
E
K
Y
Q
Q
R
L
N
A
Chicken
Gallus gallus
XP_418682
516
58625
S67
A
K
L
E
L
F
H
S
I
Q
R
T
C
M
E
Frog
Xenopus laevis
NP_001080094
512
57900
S67
A
K
L
E
L
F
H
S
I
Q
R
T
C
M
E
Zebra Danio
Brachydanio rerio
NP_001002730
449
50173
E58
A
D
L
D
A
K
L
E
V
F
H
S
V
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392866
545
62009
S75
A
K
L
E
L
F
R
S
I
Q
E
S
C
S
Y
Nematode Worm
Caenorhab. elegans
P91124
430
48887
R39
Q
R
H
Y
W
T
A
R
Q
F
I
R
T
K
L
Sea Urchin
Strong. purpuratus
XP_001198366
691
77094
S173
A
K
L
E
V
F
K
S
I
Q
N
T
C
M
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.9
94.1
N.A.
88.8
89.4
N.A.
49.2
70.3
66.2
57.3
N.A.
N.A.
39.2
35.2
37.3
Protein Similarity:
100
99.5
98.1
97
N.A.
92.9
94
N.A.
62.7
76.1
74.2
68.3
N.A.
N.A.
54.5
50
47.6
P-Site Identity:
100
100
100
100
N.A.
0
0
N.A.
13.3
86.6
86.6
13.3
N.A.
N.A.
66.6
0
66.6
P-Site Similarity:
100
100
100
100
N.A.
6.6
6.6
N.A.
33.3
100
100
33.3
N.A.
N.A.
73.3
6.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
70
0
0
0
8
0
8
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
16
62
0
0
% C
% Asp:
0
8
0
8
0
0
0
0
0
0
0
0
0
16
31
% D
% Glu:
8
0
16
62
0
0
8
8
0
0
8
0
0
0
24
% E
% Phe:
0
0
0
0
16
62
0
0
0
16
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
16
47
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
16
62
0
8
0
0
0
0
% I
% Lys:
16
62
0
8
0
8
8
8
0
0
0
0
0
8
0
% K
% Leu:
0
24
77
16
54
0
8
0
0
0
0
0
24
31
24
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
24
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
24
70
8
0
0
8
0
% Q
% Arg:
0
8
0
0
0
0
8
8
0
16
47
16
0
0
8
% R
% Ser:
0
0
0
0
0
0
16
62
0
0
0
16
0
8
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
16
54
8
0
0
% T
% Val:
0
0
0
0
8
8
0
0
8
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _