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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ICA1
All Species:
10.91
Human Site:
T421
Identified Species:
20
UniProt:
Q05084
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05084
NP_001129492.1
483
54645
T421
E
P
D
P
K
A
Q
T
G
S
G
F
L
P
S
Chimpanzee
Pan troglodytes
XP_518971
483
54670
T421
E
P
D
P
K
A
Q
T
G
S
G
F
L
P
S
Rhesus Macaque
Macaca mulatta
XP_001086048
484
54745
T422
E
P
D
P
K
P
Q
T
G
S
G
F
L
P
S
Dog
Lupus familis
XP_850551
483
54711
A421
E
P
D
P
R
P
Q
A
G
S
G
F
L
P
S
Cat
Felis silvestris
Mouse
Mus musculus
P97411
478
54364
I416
E
P
D
P
K
P
Q
I
G
S
G
F
L
P
S
Rat
Rattus norvegicus
Q63054
480
54644
I418
E
P
D
P
K
P
Q
I
G
S
A
F
L
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508894
481
54258
R421
S
V
V
V
V
V
K
R
L
L
C
A
T
H
C
Chicken
Gallus gallus
XP_418682
516
58625
S454
A
N
S
A
S
P
L
S
I
P
Q
P
A
Q
K
Frog
Xenopus laevis
NP_001080094
512
57900
S450
T
A
N
S
G
T
S
S
C
Q
A
A
P
P
A
Zebra Danio
Brachydanio rerio
NP_001002730
449
50173
S389
S
T
V
S
G
S
L
S
A
I
L
Q
N
N
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392866
545
62009
N426
D
K
S
D
T
N
F
N
L
A
D
F
S
S
L
Nematode Worm
Caenorhab. elegans
P91124
430
48887
D370
G
P
L
A
T
L
F
D
T
S
S
F
V
P
P
Sea Urchin
Strong. purpuratus
XP_001198366
691
77094
D628
Q
Y
S
D
L
F
A
D
R
M
S
A
A
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.9
94.1
N.A.
88.8
89.4
N.A.
49.2
70.3
66.2
57.3
N.A.
N.A.
39.2
35.2
37.3
Protein Similarity:
100
99.5
98.1
97
N.A.
92.9
94
N.A.
62.7
76.1
74.2
68.3
N.A.
N.A.
54.5
50
47.6
P-Site Identity:
100
100
93.3
80
N.A.
86.6
80
N.A.
0
0
6.6
0
N.A.
N.A.
6.6
26.6
0
P-Site Similarity:
100
100
93.3
86.6
N.A.
86.6
80
N.A.
6.6
6.6
26.6
13.3
N.A.
N.A.
20
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
16
0
16
8
8
8
8
16
24
16
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
8
% C
% Asp:
8
0
47
16
0
0
0
16
0
0
8
0
0
0
0
% D
% Glu:
47
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
16
0
0
0
0
62
0
0
0
% F
% Gly:
8
0
0
0
16
0
0
0
47
0
39
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
16
8
8
0
0
0
0
0
% I
% Lys:
0
8
0
0
39
0
8
0
0
0
0
0
0
0
8
% K
% Leu:
0
0
8
0
8
8
16
0
16
8
8
0
47
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
8
0
8
0
0
0
0
8
8
0
% N
% Pro:
0
54
0
47
0
39
0
0
0
8
0
8
8
62
16
% P
% Gln:
8
0
0
0
0
0
47
0
0
8
8
8
0
16
8
% Q
% Arg:
0
0
0
0
8
0
0
8
8
0
0
0
0
0
0
% R
% Ser:
16
0
24
16
8
8
8
24
0
54
16
0
8
8
47
% S
% Thr:
8
8
0
0
16
8
0
24
8
0
0
0
8
0
0
% T
% Val:
0
8
16
8
8
8
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _