KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
UBE3A
All Species:
35.15
Human Site:
Y556
Identified Species:
59.49
UniProt:
Q05086
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05086
NP_000453.2
875
100688
Y556
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Chimpanzee
Pan troglodytes
XP_510256
879
101065
Y560
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Rhesus Macaque
Macaca mulatta
XP_001108510
879
101081
Y560
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Dog
Lupus familis
XP_848240
875
100388
Y556
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
O08759
885
101157
Y567
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Rat
Rattus norvegicus
Q5PQN1
1057
118521
K739
I
D
Y
K
K
P
L
K
V
I
F
V
G
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514205
825
94298
D511
N
V
V
G
G
E
V
D
T
D
H
N
E
E
E
Chicken
Gallus gallus
XP_416882
880
100974
Y561
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Frog
Xenopus laevis
Q6DCL5
944
106566
A618
E
K
L
K
Q
G
I
A
V
R
F
H
G
E
E
Zebra Danio
Brachydanio rerio
NP_001007319
857
97523
Y538
A
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y0H4
949
107948
Y624
Y
E
L
R
R
R
L
Y
I
I
F
R
G
E
E
Honey Bee
Apis mellifera
XP_394656
898
100748
V578
S
D
L
K
K
Q
L
V
V
E
F
E
G
E
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001203179
881
99830
Y562
M
D
L
K
K
Q
L
Y
V
E
F
E
G
E
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40985
892
103438
R550
G
D
L
L
K
S
L
R
I
E
F
V
N
E
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
98.5
97.5
N.A.
92.8
26
N.A.
66.9
93.5
22.5
84.5
N.A.
23.6
48.3
N.A.
51.3
Protein Similarity:
100
99
98.9
98.4
N.A.
95.2
43.7
N.A.
73.4
96.5
40.7
90.9
N.A.
41.2
66.5
N.A.
69.2
P-Site Identity:
100
100
100
100
N.A.
100
53.3
N.A.
6.6
100
40
100
N.A.
40
86.6
N.A.
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
53.3
N.A.
40
100
60
100
N.A.
80
93.3
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
79
0
0
0
0
0
8
0
8
0
0
0
0
8
% D
% Glu:
8
8
0
0
0
8
0
0
0
72
0
65
8
100
22
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
93
0
0
0
0
% F
% Gly:
8
0
0
8
8
8
0
0
0
0
0
0
86
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
15
15
0
0
0
0
0
% I
% Lys:
0
8
0
79
79
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
86
8
0
0
86
0
0
0
0
0
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
8
65
0
0
0
0
0
0
0
0
65
% Q
% Arg:
0
0
0
8
8
8
0
8
0
8
0
8
0
0
0
% R
% Ser:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
0
8
8
0
0
0
8
8
79
0
0
15
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
0
0
65
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _