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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
UBE3A
All Species:
34.55
Human Site:
Y717
Identified Species:
58.46
UniProt:
Q05086
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05086
NP_000453.2
875
100688
Y717
R
K
E
F
V
N
L
Y
S
D
Y
I
L
N
K
Chimpanzee
Pan troglodytes
XP_510256
879
101065
Y721
R
K
E
F
V
N
L
Y
S
D
Y
I
L
N
K
Rhesus Macaque
Macaca mulatta
XP_001108510
879
101081
Y721
R
K
E
F
V
N
L
Y
S
D
Y
I
L
N
K
Dog
Lupus familis
XP_848240
875
100388
Y717
R
K
E
F
V
N
L
Y
S
D
Y
I
L
N
K
Cat
Felis silvestris
Mouse
Mus musculus
O08759
885
101157
Y727
R
K
E
F
V
I
S
Y
S
D
Y
I
L
N
K
Rat
Rattus norvegicus
Q5PQN1
1057
118521
Y900
R
Q
E
F
V
D
A
Y
V
D
Y
I
F
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514205
825
94298
E668
R
L
E
M
I
A
M
E
N
P
A
D
L
K
K
Chicken
Gallus gallus
XP_416882
880
100974
Y722
R
K
E
F
V
N
L
Y
A
D
Y
I
L
N
K
Frog
Xenopus laevis
Q6DCL5
944
106566
V779
K
A
E
Y
V
Q
L
V
T
E
L
R
M
T
R
Zebra Danio
Brachydanio rerio
NP_001007319
857
97523
Y699
R
K
D
F
V
A
L
Y
A
E
Y
M
L
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y0H4
949
107948
M787
K
E
E
Y
I
T
L
M
T
E
W
R
M
T
R
Honey Bee
Apis mellifera
XP_394656
898
100748
L739
N
K
K
E
F
V
D
L
Y
A
D
F
L
L
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001203179
881
99830
Y723
R
K
E
F
V
D
L
Y
A
D
F
I
L
N
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40985
892
103438
Q720
G
R
N
V
P
I
T
Q
S
N
K
H
E
F
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
98.5
97.5
N.A.
92.8
26
N.A.
66.9
93.5
22.5
84.5
N.A.
23.6
48.3
N.A.
51.3
Protein Similarity:
100
99
98.9
98.4
N.A.
95.2
43.7
N.A.
73.4
96.5
40.7
90.9
N.A.
41.2
66.5
N.A.
69.2
P-Site Identity:
100
100
100
100
N.A.
86.6
66.6
N.A.
26.6
93.3
20
66.6
N.A.
13.3
13.3
N.A.
73.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
80
N.A.
46.6
100
60
93.3
N.A.
73.3
20
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
15
8
0
22
8
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
15
8
0
0
58
8
8
0
0
0
% D
% Glu:
0
8
79
8
0
0
0
8
0
22
0
0
8
0
0
% E
% Phe:
0
0
0
65
8
0
0
0
0
0
8
8
8
8
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
15
15
0
0
0
0
0
58
0
0
0
% I
% Lys:
15
65
8
0
0
0
0
0
0
0
8
0
0
8
65
% K
% Leu:
0
8
0
0
0
0
65
8
0
0
8
0
72
8
0
% L
% Met:
0
0
0
8
0
0
8
8
0
0
0
8
15
0
0
% M
% Asn:
8
0
8
0
0
36
0
0
8
8
0
0
0
65
8
% N
% Pro:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
8
0
8
0
0
0
0
0
0
0
% Q
% Arg:
72
8
0
0
0
0
0
0
0
0
0
15
0
0
22
% R
% Ser:
0
0
0
0
0
0
8
0
43
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
8
0
15
0
0
0
0
15
0
% T
% Val:
0
0
0
8
72
8
0
8
8
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
15
0
0
0
65
8
0
58
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _