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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
UBE3A
All Species:
27.27
Human Site:
Y748
Identified Species:
46.15
UniProt:
Q05086
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05086
NP_000453.2
875
100688
Y748
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Chimpanzee
Pan troglodytes
XP_510256
879
101065
Y752
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Rhesus Macaque
Macaca mulatta
XP_001108510
879
101081
Y752
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Dog
Lupus familis
XP_848240
875
100388
Y748
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Cat
Felis silvestris
Mouse
Mus musculus
O08759
885
101157
Y758
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Rat
Rattus norvegicus
Q5PQN1
1057
118521
L930
V
C
G
G
K
V
L
L
L
F
Q
P
N
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514205
825
94298
L699
V
S
K
E
F
F
Q
L
V
V
E
E
I
F
N
Chicken
Gallus gallus
XP_416882
880
100974
Y753
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Frog
Xenopus laevis
Q6DCL5
944
106566
Q809
F
I
P
P
S
L
I
Q
L
F
D
E
Y
E
L
Zebra Danio
Brachydanio rerio
NP_001007319
857
97523
Y730
T
N
E
S
P
L
K
Y
L
F
R
P
E
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y0H4
949
107948
K817
V
V
P
L
E
W
L
K
Y
F
D
E
R
E
L
Honey Bee
Apis mellifera
XP_394656
898
100748
L771
T
D
E
S
P
L
A
L
L
F
R
P
E
E
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001203179
881
99830
N754
T
D
E
S
P
L
R
N
W
F
R
P
D
E
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40985
892
103438
N764
C
N
S
I
K
L
F
N
S
E
E
L
E
R
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
98.5
97.5
N.A.
92.8
26
N.A.
66.9
93.5
22.5
84.5
N.A.
23.6
48.3
N.A.
51.3
Protein Similarity:
100
99
98.9
98.4
N.A.
95.2
43.7
N.A.
73.4
96.5
40.7
90.9
N.A.
41.2
66.5
N.A.
69.2
P-Site Identity:
100
100
100
100
N.A.
100
26.6
N.A.
0
100
26.6
100
N.A.
13.3
80
N.A.
60
P-Site Similarity:
100
100
100
100
N.A.
100
46.6
N.A.
26.6
100
33.3
100
N.A.
20
86.6
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
0
0
0
0
0
0
0
0
15
0
8
0
0
% D
% Glu:
0
0
65
8
8
0
0
0
0
8
15
22
65
86
0
% E
% Phe:
8
0
0
0
8
8
8
0
0
86
0
0
0
8
0
% F
% Gly:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
8
0
0
8
0
0
0
0
0
8
0
58
% I
% Lys:
0
0
8
0
15
0
50
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
0
79
15
22
72
0
0
8
0
0
29
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
58
0
0
0
0
0
15
0
0
0
0
8
0
8
% N
% Pro:
0
0
15
8
65
0
0
0
0
0
0
72
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
8
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
65
0
8
8
0
% R
% Ser:
0
8
8
65
8
0
0
0
8
0
0
0
0
0
0
% S
% Thr:
65
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
22
8
0
0
0
8
0
0
8
8
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _