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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
24.24
Human Site:
S324
Identified Species:
53.33
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
S324
N
T
E
N
M
I
S
S
I
E
P
E
K
Q
D
Chimpanzee
Pan troglodytes
XP_519168
792
88529
S336
N
T
E
N
M
V
S
S
I
E
P
E
K
Q
D
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
L293
V
H
R
A
I
A
Q
L
F
E
K
Q
L
Q
L
Dog
Lupus familis
XP_540396
757
85032
S299
N
T
E
N
M
V
S
S
I
D
P
D
K
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
S323
T
T
G
T
M
V
S
S
I
D
S
E
K
Q
D
Rat
Rattus norvegicus
NP_476456
766
85965
S323
S
T
G
N
M
V
S
S
I
D
S
E
K
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
S300
S
T
E
N
I
V
S
S
I
D
L
E
K
Q
D
Chicken
Gallus gallus
XP_415970
1211
131521
S747
N
T
E
N
A
V
S
S
S
D
A
Q
K
Q
D
Frog
Xenopus laevis
NP_001084841
660
74123
Q220
I
G
L
M
R
H
Y
Q
A
H
D
D
V
P
L
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
C130
V
A
V
I
V
M
A
C
R
E
F
E
M
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
N352
S
H
N
Y
V
N
C
N
V
T
P
K
G
V
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
93.3
13.3
80
N.A.
60
66.6
N.A.
66.6
60
0
13.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
26.6
100
N.A.
73.3
86.6
N.A.
93.3
80
6.6
33.3
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
10
10
10
10
0
10
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
46
10
19
0
0
64
% D
% Glu:
0
0
46
0
0
0
0
0
0
37
0
55
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% F
% Gly:
0
10
19
0
0
0
0
0
0
0
0
0
10
10
0
% G
% His:
0
19
0
0
0
10
0
0
0
10
0
0
0
0
0
% H
% Ile:
10
0
0
10
19
10
0
0
55
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
10
10
64
0
0
% K
% Leu:
0
0
10
0
0
0
0
10
0
0
10
0
10
0
19
% L
% Met:
0
0
0
10
46
10
0
0
0
0
0
0
10
0
0
% M
% Asn:
37
0
10
55
0
10
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
37
0
0
10
0
% P
% Gln:
0
0
0
0
0
0
10
10
0
0
0
19
0
73
0
% Q
% Arg:
0
0
10
0
10
0
0
0
10
0
0
0
0
0
10
% R
% Ser:
28
0
0
0
0
0
64
64
10
0
19
0
0
0
10
% S
% Thr:
10
64
0
10
0
0
0
0
0
10
0
0
0
0
0
% T
% Val:
19
0
10
0
19
55
0
0
10
0
0
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _