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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKCZ
All Species:
24.85
Human Site:
Y214
Identified Species:
54.67
UniProt:
Q05513
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05513
NP_001028753.1
592
67660
Y214
E
E
T
D
G
I
A
Y
I
S
S
S
R
K
H
Chimpanzee
Pan troglodytes
XP_001148501
597
67369
Y219
E
E
T
D
G
I
A
Y
I
S
S
S
R
K
H
Rhesus Macaque
Macaca mulatta
XP_001089400
597
68263
Y220
H
A
Q
T
V
I
P
Y
N
P
S
S
H
E
S
Dog
Lupus familis
XP_849092
591
67659
Y213
E
D
T
H
G
I
A
Y
I
S
S
T
R
K
H
Cat
Felis silvestris
Mouse
Mus musculus
Q02956
592
67606
Y214
E
E
T
D
G
I
A
Y
I
S
S
S
R
K
H
Rat
Rattus norvegicus
P09217
592
67715
Y214
E
E
T
D
G
I
A
Y
I
S
S
S
R
K
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417561
606
69931
Y228
E
E
N
D
G
I
P
Y
I
P
S
N
R
K
H
Frog
Xenopus laevis
Q6IP76
485
56005
K150
A
M
S
K
G
R
P
K
V
T
M
N
D
F
D
Zebra Danio
Brachydanio rerio
Q90XF2
588
67303
G211
E
H
P
D
Q
V
L
G
K
K
N
S
T
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13678
634
71138
T264
V
D
S
L
A
T
S
T
T
T
M
T
S
G
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19266
597
68017
G213
S
T
T
R
S
G
G
G
I
D
N
G
A
F
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.4
70
94.7
N.A.
95.4
95.9
N.A.
N.A.
87.9
33.1
70.7
N.A.
36.5
N.A.
56.6
N.A.
Protein Similarity:
100
93.1
81.5
97.1
N.A.
96.9
97.3
N.A.
N.A.
92.7
50.1
81.9
N.A.
54.8
N.A.
70.5
N.A.
P-Site Identity:
100
100
26.6
80
N.A.
100
100
N.A.
N.A.
73.3
6.6
20
N.A.
0
N.A.
20
N.A.
P-Site Similarity:
100
100
33.3
93.3
N.A.
100
100
N.A.
N.A.
80
33.3
40
N.A.
40
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
10
0
46
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
19
0
55
0
0
0
0
0
10
0
0
10
0
10
% D
% Glu:
64
46
0
0
0
0
0
0
0
0
0
0
0
19
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% F
% Gly:
0
0
0
0
64
10
10
19
0
0
0
10
0
10
0
% G
% His:
10
10
0
10
0
0
0
0
0
0
0
0
10
0
64
% H
% Ile:
0
0
0
0
0
64
0
0
64
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
0
0
0
10
10
10
0
0
0
55
0
% K
% Leu:
0
0
0
10
0
0
10
0
0
0
0
0
0
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
19
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
10
0
19
19
0
0
0
% N
% Pro:
0
0
10
0
0
0
28
0
0
19
0
0
0
0
0
% P
% Gln:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
10
0
0
0
0
0
0
55
0
0
% R
% Ser:
10
0
19
0
10
0
10
0
0
46
64
55
10
0
19
% S
% Thr:
0
10
55
10
0
10
0
10
10
19
0
19
10
0
0
% T
% Val:
10
0
0
0
10
10
0
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
64
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _