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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FPGS All Species: 12.42
Human Site: S488 Identified Species: 22.78
UniProt: Q05932 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05932 NP_001018088.1 587 64609 S488 Q A S P D L W S A P S P E P G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001094027 589 64667 S490 Q A S P D L W S A P S P E P A
Dog Lupus familis XP_851481 588 64991 S489 H A S P N L W S P T S L E P G
Cat Felis silvestris
Mouse Mus musculus P48760 587 64889 S488 Q A S S N L W S S C G P D P A
Rat Rattus norvegicus NP_001139597 587 65251 G488 Q A S S N L W G S C G P E S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_998602 572 63143 G475 Q S W R V L N G L E E K P E A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_397249 440 49749 S343 D G A H T I E S I K C C I S W
Nematode Worm Caenorhab. elegans Q09509 510 56414 I413 K P L G I S Q I V S C P T Q L
Sea Urchin Strong. purpuratus XP_796835 647 71198 Q534 Q A S G S L H Q Q T V Q Y T P
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001152065 557 61781 Q460 H A L F V P N Q S Q Y N K L G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_196217 571 63327 M474 K A L F V P N M S V Y H K V G
Baker's Yeast Sacchar. cerevisiae Q08645 548 62133 T449 S S V S P E I T F D D V I F T
Red Bread Mold Neurospora crassa O13492 528 58506 F431 T G F S H V I F C T N V T Y A
Conservation
Percent
Protein Identity: 100 N.A. 93.8 87 N.A. 81.4 80.9 N.A. N.A. N.A. N.A. 59.9 N.A. N.A. 32.8 35.9 41.1
Protein Similarity: 100 N.A. 95.9 91.6 N.A. 87.9 87.7 N.A. N.A. N.A. N.A. 72.4 N.A. N.A. 50.9 50.9 55.3
P-Site Identity: 100 N.A. 93.3 66.6 N.A. 53.3 46.6 N.A. N.A. N.A. N.A. 13.3 N.A. N.A. 6.6 6.6 26.6
P-Site Similarity: 100 N.A. 93.3 73.3 N.A. 73.3 60 N.A. N.A. N.A. N.A. 20 N.A. N.A. 20 13.3 26.6
Percent
Protein Identity: N.A. 35.6 N.A. 35.6 37.1 34.7
Protein Similarity: N.A. 49.2 N.A. 50.9 52.1 50.4
P-Site Identity: N.A. 13.3 N.A. 13.3 0 0
P-Site Similarity: N.A. 26.6 N.A. 33.3 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 62 8 0 0 0 0 0 16 0 0 0 0 0 39 % A
% Cys: 0 0 0 0 0 0 0 0 8 16 16 8 0 0 0 % C
% Asp: 8 0 0 0 16 0 0 0 0 8 8 0 8 0 0 % D
% Glu: 0 0 0 0 0 8 8 0 0 8 8 0 31 8 0 % E
% Phe: 0 0 8 16 0 0 0 8 8 0 0 0 0 8 0 % F
% Gly: 0 16 0 16 0 0 0 16 0 0 16 0 0 0 31 % G
% His: 16 0 0 8 8 0 8 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 0 8 8 16 8 8 0 0 0 16 0 0 % I
% Lys: 16 0 0 0 0 0 0 0 0 8 0 8 16 0 0 % K
% Leu: 0 0 24 0 0 54 0 0 8 0 0 8 0 8 8 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 24 0 24 0 0 0 8 8 0 0 0 % N
% Pro: 0 8 0 24 8 16 0 0 8 16 0 39 8 31 8 % P
% Gln: 47 0 0 0 0 0 8 16 8 8 0 8 0 8 0 % Q
% Arg: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 16 47 31 8 8 0 39 31 8 24 0 0 16 0 % S
% Thr: 8 0 0 0 8 0 0 8 0 24 0 0 16 8 8 % T
% Val: 0 0 8 0 24 8 0 0 8 8 8 16 0 8 0 % V
% Trp: 0 0 8 0 0 0 39 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 16 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _