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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FPGS All Species: 15.76
Human Site: S499 Identified Species: 28.89
UniProt: Q05932 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05932 NP_001018088.1 587 64609 S499 P E P G G S A S L L L A P H P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001094027 589 64667 S501 P E P A G P T S L L L A P H P
Dog Lupus familis XP_851481 588 64991 S500 L E P G E P T S L L L A S H Q
Cat Felis silvestris
Mouse Mus musculus P48760 587 64889 S499 P D P A G P G S L L L A P H P
Rat Rattus norvegicus NP_001139597 587 65251 S499 P E S A R P G S L L L A P H P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_998602 572 63143 I486 K P E A E L L I G G G L P L V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_397249 440 49749 I354 C I S W F N D I R I K S L D D
Nematode Worm Caenorhab. elegans Q09509 510 56414 I424 P T Q L H S S I D K S A D S A
Sea Urchin Strong. purpuratus XP_796835 647 71198 V545 Q Y T P T N V V D Q P S S T C
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001152065 557 61781 S471 N K L G S L A S P P S E R E Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_196217 571 63327 D485 H K V G T A A D L P E N D P Q
Baker's Yeast Sacchar. cerevisiae Q08645 548 62133 T460 V I F T T N V T W K S G S Y S
Red Bread Mold Neurospora crassa O13492 528 58506 Y442 V T Y A T T G Y K K D F V N H
Conservation
Percent
Protein Identity: 100 N.A. 93.8 87 N.A. 81.4 80.9 N.A. N.A. N.A. N.A. 59.9 N.A. N.A. 32.8 35.9 41.1
Protein Similarity: 100 N.A. 95.9 91.6 N.A. 87.9 87.7 N.A. N.A. N.A. N.A. 72.4 N.A. N.A. 50.9 50.9 55.3
P-Site Identity: 100 N.A. 80 60 N.A. 73.3 66.6 N.A. N.A. N.A. N.A. 6.6 N.A. N.A. 0 20 0
P-Site Similarity: 100 N.A. 80 60 N.A. 80 66.6 N.A. N.A. N.A. N.A. 6.6 N.A. N.A. 20 26.6 13.3
Percent
Protein Identity: N.A. 35.6 N.A. 35.6 37.1 34.7
Protein Similarity: N.A. 49.2 N.A. 50.9 52.1 50.4
P-Site Identity: N.A. 20 N.A. 20 0 0
P-Site Similarity: N.A. 26.6 N.A. 33.3 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 39 0 8 24 0 0 0 0 47 0 0 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 8 0 0 0 0 8 8 16 0 8 0 16 8 8 % D
% Glu: 0 31 8 0 16 0 0 0 0 0 8 8 0 8 0 % E
% Phe: 0 0 8 0 8 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 31 24 0 24 0 8 8 8 8 0 0 0 % G
% His: 8 0 0 0 8 0 0 0 0 0 0 0 0 39 8 % H
% Ile: 0 16 0 0 0 0 0 24 0 8 0 0 0 0 0 % I
% Lys: 8 16 0 0 0 0 0 0 8 24 8 0 0 0 0 % K
% Leu: 8 0 8 8 0 16 8 0 47 39 39 8 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 24 0 0 0 0 0 8 0 8 0 % N
% Pro: 39 8 31 8 0 31 0 0 8 16 8 0 39 8 31 % P
% Gln: 8 0 8 0 0 0 0 0 0 8 0 0 0 0 24 % Q
% Arg: 0 0 0 0 8 0 0 0 8 0 0 0 8 0 0 % R
% Ser: 0 0 16 0 8 16 8 47 0 0 24 16 24 8 8 % S
% Thr: 0 16 8 8 31 8 16 8 0 0 0 0 0 8 0 % T
% Val: 16 0 8 0 0 0 16 8 0 0 0 0 8 0 8 % V
% Trp: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 8 8 0 0 0 0 8 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _