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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN11
All Species:
19.39
Human Site:
T570
Identified Species:
42.67
UniProt:
Q06124
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06124
NP_002825.3
597
68436
T570
P
L
P
P
C
T
P
T
P
P
C
A
E
M
R
Chimpanzee
Pan troglodytes
XP_001164543
512
58884
T485
P
L
P
P
C
T
P
T
P
P
C
A
E
M
R
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
K562
S
R
T
S
S
K
H
K
E
D
V
Y
E
N
L
Dog
Lupus familis
XP_534686
571
65327
I545
K
G
H
E
Y
T
N
I
K
Y
S
L
T
D
Q
Cat
Felis silvestris
Mouse
Mus musculus
P35235
597
68442
T570
P
L
P
P
C
T
P
T
P
P
C
A
E
M
R
Rat
Rattus norvegicus
P41499
597
68440
T570
P
L
P
P
C
T
P
T
P
P
C
A
E
M
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519242
359
41028
V333
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
Chicken
Gallus gallus
Q90687
593
67964
T566
P
L
P
P
C
T
P
T
P
T
C
P
E
M
R
Frog
Xenopus laevis
NP_001084076
595
68232
L566
P
P
C
T
P
T
P
L
P
T
P
T
L
P
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
S690
P
L
P
P
A
I
S
S
I
S
L
V
P
S
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
P507
N
V
Y
Q
N
V
G
P
I
N
N
M
S
T
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.7
54
95.1
N.A.
99.5
98.9
N.A.
59.2
97.6
93.4
N.A.
N.A.
38.5
N.A.
N.A.
51.9
Protein Similarity:
100
85.7
70
95.1
N.A.
99.8
99.5
N.A.
60.1
98.4
95.8
N.A.
N.A.
51.3
N.A.
N.A.
65.8
P-Site Identity:
100
100
6.6
6.6
N.A.
100
100
N.A.
6.6
86.6
26.6
N.A.
N.A.
26.6
N.A.
N.A.
0
P-Site Similarity:
100
100
6.6
13.3
N.A.
100
100
N.A.
6.6
86.6
26.6
N.A.
N.A.
40
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
0
0
0
0
37
0
0
0
% A
% Cys:
0
0
19
0
46
0
0
0
0
0
46
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
19
0
0
0
10
0
% D
% Glu:
0
0
0
10
0
0
0
0
10
0
0
0
55
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
0
19
0
0
0
0
10
0
0
0
0
0
0
0
0
% G
% His:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
10
19
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
10
0
10
10
0
0
0
0
0
10
% K
% Leu:
0
55
0
10
0
0
0
10
0
0
10
10
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
55
0
% M
% Asn:
10
0
0
0
10
10
10
0
10
10
10
0
0
10
0
% N
% Pro:
64
10
55
55
10
0
55
10
55
37
10
10
10
10
10
% P
% Gln:
10
0
0
10
10
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
46
% R
% Ser:
10
0
0
10
10
0
10
10
0
10
10
0
10
10
0
% S
% Thr:
0
0
10
10
0
64
10
46
0
19
0
10
10
10
0
% T
% Val:
0
10
0
0
0
10
0
10
0
0
10
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% W
% Tyr:
0
0
10
0
10
0
0
0
0
10
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _