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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK18 All Species: 36.97
Human Site: S289 Identified Species: 67.78
UniProt: Q07002 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q07002 NP_002587.2 472 54180 S289 F G L A R A K S V P T K T Y S
Chimpanzee Pan troglodytes XP_521035 762 83144 S578 F G L A R A K S I P T K T Y S
Rhesus Macaque Macaca mulatta XP_001100911 485 54881 S301 F G L A R A K S I P T K T Y S
Dog Lupus familis XP_539731 541 61618 S357 F G L A R A K S V P T K T Y S
Cat Felis silvestris
Mouse Mus musculus Q04899 451 51829 S268 F G L A R A K S V P T K T Y S
Rat Rattus norvegicus O35832 451 51863 S268 F G L A R A K S V P T K T Y S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510894 523 59528 S339 F G L A R A K S V P T K T Y S
Chicken Gallus gallus XP_001234978 430 49073 S247 F G L A R A K S V P T K T Y S
Frog Xenopus laevis Q6DJM7 435 49211 S248 F G L A R A K S V P S H T Y S
Zebra Danio Brachydanio rerio Q1RLU9 418 47889 S238 S I P C Q T Y S A E V V T L W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48609 294 33162 L114 M L Q L L R G L A F C H S H N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 G114 Y L Y Q I L H G V A Y C H S H
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 G114 Y L Y Q I L R G I A Y C H S H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 44.3 61.4 61.3 N.A. 87.7 88.1 N.A. 63.8 76.4 46.1 43.8 N.A. 34.1 N.A. N.A. N.A.
Protein Similarity: 100 53.1 75.2 73.9 N.A. 92.5 92.8 N.A. 77.4 81.9 61.6 57.4 N.A. 44 N.A. N.A. N.A.
P-Site Identity: 100 93.3 93.3 100 N.A. 100 100 N.A. 100 100 86.6 13.3 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 93.3 20 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. 33 N.A. 33.2 N.A. N.A.
Protein Similarity: N.A. 47 N.A. 47.8 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 13.3 N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 70 0 70 0 0 16 16 0 0 0 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 8 16 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % E
% Phe: 70 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 0 70 0 0 0 0 8 16 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 16 16 8 16 % H
% Ile: 0 8 0 0 16 0 0 0 24 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 70 0 0 0 0 62 0 0 0 % K
% Leu: 0 24 70 8 8 16 0 8 0 0 0 0 0 8 0 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 8 0 0 0 0 0 0 70 0 0 0 0 0 % P
% Gln: 0 0 8 16 8 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 70 8 8 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 0 0 0 0 0 77 0 0 8 0 8 16 70 % S
% Thr: 0 0 0 0 0 8 0 0 0 0 62 0 77 0 0 % T
% Val: 0 0 0 0 0 0 0 0 62 0 8 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 16 0 16 0 0 0 8 0 0 0 16 0 0 70 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _