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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK18
All Species:
1.52
Human Site:
S421
Identified Species:
2.78
UniProt:
Q07002
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07002
NP_002587.2
472
54180
S421
A
E
A
A
L
S
H
S
Y
F
R
S
L
G
E
Chimpanzee
Pan troglodytes
XP_521035
762
83144
P710
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
Rhesus Macaque
Macaca mulatta
XP_001100911
485
54881
P433
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
Dog
Lupus familis
XP_539731
541
61618
V489
A
E
E
A
M
K
H
V
Y
F
R
S
L
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q04899
451
51829
P400
A
E
A
A
L
N
H
P
Y
F
Q
S
L
G
D
Rat
Rattus norvegicus
O35832
451
51863
P400
A
E
A
A
L
S
H
P
Y
F
Q
S
L
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510894
523
59528
A471
A
E
E
A
M
K
H
A
Y
F
R
S
L
G
T
Chicken
Gallus gallus
XP_001234978
430
49073
P379
A
E
V
A
L
R
H
P
Y
F
K
S
L
G
E
Frog
Xenopus laevis
Q6DJM7
435
49211
L380
R
L
S
A
Q
A
A
L
N
H
D
Y
F
S
D
Zebra Danio
Brachydanio rerio
Q1RLU9
418
47889
N370
A
L
L
H
P
Y
F
N
T
L
P
P
P
L
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48609
294
33162
T246
L
P
S
F
P
A
I
T
S
W
S
Q
L
V
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
A246
T
A
F
P
R
W
Q
A
Q
D
L
A
T
V
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
P246
S
A
F
P
K
W
K
P
T
D
L
E
T
F
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
44.3
61.4
61.3
N.A.
87.7
88.1
N.A.
63.8
76.4
46.1
43.8
N.A.
34.1
N.A.
N.A.
N.A.
Protein Similarity:
100
53.1
75.2
73.9
N.A.
92.5
92.8
N.A.
77.4
81.9
61.6
57.4
N.A.
44
N.A.
N.A.
N.A.
P-Site Identity:
100
60
60
66.6
N.A.
73.3
86.6
N.A.
66.6
73.3
6.6
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
73.3
73.3
73.3
N.A.
93.3
93.3
N.A.
80
80
26.6
13.3
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
33
N.A.
33.2
N.A.
N.A.
Protein Similarity:
N.A.
47
N.A.
47.8
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
70
16
24
70
0
16
8
16
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
16
0
0
0
0
0
0
16
8
0
0
0
16
% D
% Glu:
0
62
16
0
0
0
0
0
0
0
0
8
0
0
39
% E
% Phe:
0
0
16
8
0
0
8
0
16
62
0
0
8
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
62
0
% G
% His:
0
0
0
8
0
0
62
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
31
8
0
0
0
8
0
0
0
0
% K
% Leu:
8
16
8
0
31
0
0
8
0
8
31
0
70
8
0
% L
% Met:
0
0
0
0
31
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
8
0
8
8
0
0
0
0
0
0
% N
% Pro:
0
8
0
16
16
0
0
47
0
0
8
8
8
0
16
% P
% Gln:
0
0
0
0
8
0
8
0
8
0
16
8
0
0
0
% Q
% Arg:
8
0
0
0
8
8
0
0
0
0
24
0
0
0
0
% R
% Ser:
8
0
16
0
0
16
0
8
8
0
8
62
0
8
0
% S
% Thr:
8
0
0
0
0
0
0
8
16
0
0
0
16
0
8
% T
% Val:
0
0
8
0
0
0
0
8
0
0
0
0
0
16
16
% V
% Trp:
0
0
0
0
0
16
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
47
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _