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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCL1
All Species:
10
Human Site:
S150
Identified Species:
27.5
UniProt:
Q07820
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07820
NP_068779.1
350
37337
S150
L
L
E
L
V
G
E
S
G
N
N
T
S
T
D
Chimpanzee
Pan troglodytes
XP_513776
350
37318
S150
L
L
E
L
V
G
E
S
G
N
N
T
S
T
D
Rhesus Macaque
Macaca mulatta
XP_001102283
350
37185
S150
L
L
E
L
V
G
E
S
G
N
S
P
S
T
D
Dog
Lupus familis
XP_545888
237
26870
L73
D
C
E
F
G
Y
T
L
A
L
A
Q
D
Y
V
Cat
Felis silvestris
Mouse
Mus musculus
P97287
331
35199
A131
L
L
E
R
V
S
E
A
A
K
S
S
G
A
D
Rat
Rattus norvegicus
Q9Z1P3
330
35196
A130
L
L
E
R
V
S
E
A
A
K
S
S
G
A
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233735
124
13778
Frog
Xenopus laevis
NP_001131055
275
30376
Y109
Q
Q
L
I
L
A
F
Y
R
V
Y
S
G
E
E
Zebra Danio
Brachydanio rerio
NP_571674
255
28643
Q91
E
L
E
R
D
T
R
Q
L
L
L
D
F
Y
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.2
97.1
21.7
N.A.
77.1
78.5
N.A.
N.A.
26
34.5
30
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.2
98.8
34.5
N.A.
84
83.4
N.A.
N.A.
30.2
48.2
44
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
6.6
N.A.
40
40
N.A.
N.A.
0
0
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
6.6
N.A.
60
60
N.A.
N.A.
0
26.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
12
0
23
34
0
12
0
0
23
0
% A
% Cys:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
0
12
0
0
0
0
0
0
12
12
0
56
% D
% Glu:
12
0
78
0
0
0
56
0
0
0
0
0
0
12
12
% E
% Phe:
0
0
0
12
0
0
12
0
0
0
0
0
12
0
0
% F
% Gly:
0
0
0
0
12
34
0
0
34
0
0
0
34
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
23
0
0
0
0
0
% K
% Leu:
56
67
12
34
12
0
0
12
12
23
12
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
34
23
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% P
% Gln:
12
12
0
0
0
0
0
12
0
0
0
12
0
0
0
% Q
% Arg:
0
0
0
34
0
0
12
0
12
0
0
0
0
0
12
% R
% Ser:
0
0
0
0
0
23
0
34
0
0
34
34
34
0
0
% S
% Thr:
0
0
0
0
0
12
12
0
0
0
0
23
0
34
0
% T
% Val:
0
0
0
0
56
0
0
0
0
12
0
0
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
12
0
0
12
0
0
23
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _