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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLE All Species: 12.12
Human Site: Y1381 Identified Species: 29.63
UniProt: Q07864 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q07864 NP_006222.2 2286 261518 Y1381 K A E E G A S Y R K V N R V L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_543348 2273 260734 Y1374 K A E E G P S Y R K V S R V L
Cat Felis silvestris
Mouse Mus musculus Q9WVF7 2283 262009 Y1380 K A E D G P A Y R K V N R A L
Rat Rattus norvegicus NP_001100622 1515 174729 D689 L K S S S L Q D F D I R T I L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001233985 2277 260654 Y1372 K P E E G A V Y R K V N R I L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001121995 2284 262166 C1380 K Q E E A A T C K K V N R I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524462 2236 256683 W1377 P P E E G Q L W R K V N R V L
Honey Bee Apis mellifera XP_393171 2183 252634 R1355 E K D F H Q L R L V V P R I F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002328167 2221 254636 G1371 P A M E N F P G R R V T K T L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P21951 2222 255653 K1372 T M P L Q K I K N C L I E K S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 90.7 N.A. 90.5 60.7 N.A. N.A. 83.7 N.A. 80 N.A. 55.2 54.6 N.A. N.A.
Protein Similarity: 100 N.A. N.A. 94.6 N.A. 95 63.5 N.A. N.A. 92 N.A. 90.2 N.A. 71.9 71.5 N.A. N.A.
P-Site Identity: 100 N.A. N.A. 86.6 N.A. 73.3 6.6 N.A. N.A. 80 N.A. 60 N.A. 66.6 13.3 N.A. N.A.
P-Site Similarity: 100 N.A. N.A. 93.3 N.A. 86.6 20 N.A. N.A. 86.6 N.A. 80 N.A. 73.3 33.3 N.A. N.A.
Percent
Protein Identity: 43.5 N.A. N.A. N.A. 40.5 N.A.
Protein Similarity: 62.7 N.A. N.A. N.A. 60.1 N.A.
P-Site Identity: 33.3 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 46.6 N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 40 0 0 10 30 10 0 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 10 0 0 0 0 0 % C
% Asp: 0 0 10 10 0 0 0 10 0 10 0 0 0 0 0 % D
% Glu: 10 0 60 60 0 0 0 0 0 0 0 0 10 0 0 % E
% Phe: 0 0 0 10 0 10 0 0 10 0 0 0 0 0 10 % F
% Gly: 0 0 0 0 50 0 0 10 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 10 0 0 0 10 10 0 40 0 % I
% Lys: 50 20 0 0 0 10 0 10 10 60 0 0 10 10 0 % K
% Leu: 10 0 0 10 0 10 20 0 10 0 10 0 0 0 80 % L
% Met: 0 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 0 10 0 0 50 0 0 0 % N
% Pro: 20 20 10 0 0 20 10 0 0 0 0 10 0 0 0 % P
% Gln: 0 10 0 0 10 20 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 10 60 10 0 10 70 0 0 % R
% Ser: 0 0 10 10 10 0 20 0 0 0 0 10 0 0 10 % S
% Thr: 10 0 0 0 0 0 10 0 0 0 0 10 10 10 0 % T
% Val: 0 0 0 0 0 0 10 0 0 10 80 0 0 30 0 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 40 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _