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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SOS1 All Species: 18.18
Human Site: S1173 Identified Species: 57.14
UniProt: Q07889 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q07889 NP_005624.2 1333 152464 S1173 S S P S K I M S K H L D S P P
Chimpanzee Pan troglodytes XP_515425 1598 179688 S1438 S S P S K I M S K H L D S P P
Rhesus Macaque Macaca mulatta XP_001103238 1312 149667 S1152 S S P S K I M S K H L D S P P
Dog Lupus familis XP_540157 1342 152915 S1182 S S P S K I M S K H L D S P P
Cat Felis silvestris
Mouse Mus musculus Q62245 1319 150865 S1159 S S P S K I M S K H L D S P P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509981 1303 148422 P1144 R T P L T P P P A S A A S S T
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26675 1596 177916 K1363 S C A D M A Q K R Q A P D A P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782335 1310 150821 P1149 D R L H D I P P L P P R F N H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.3 95.7 96.8 N.A. 96.6 N.A. N.A. 87.4 N.A. N.A. N.A. N.A. 40.6 N.A. N.A. 50.5
Protein Similarity: 100 83.4 96.3 97.6 N.A. 97.9 N.A. N.A. 90.3 N.A. N.A. N.A. N.A. 56.6 N.A. N.A. 67.7
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. 13.3 N.A. N.A. N.A. N.A. 13.3 N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 20 N.A. N.A. N.A. N.A. 20 N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 13 0 0 13 0 0 13 0 25 13 0 13 0 % A
% Cys: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 13 0 0 13 13 0 0 0 0 0 0 63 13 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 13 0 0 0 0 0 63 0 0 0 0 13 % H
% Ile: 0 0 0 0 0 75 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 63 0 0 13 63 0 0 0 0 0 0 % K
% Leu: 0 0 13 13 0 0 0 0 13 0 63 0 0 0 0 % L
% Met: 0 0 0 0 13 0 63 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 13 0 % N
% Pro: 0 0 75 0 0 13 25 25 0 13 13 13 0 63 75 % P
% Gln: 0 0 0 0 0 0 13 0 0 13 0 0 0 0 0 % Q
% Arg: 13 13 0 0 0 0 0 0 13 0 0 13 0 0 0 % R
% Ser: 75 63 0 63 0 0 0 63 0 13 0 0 75 13 0 % S
% Thr: 0 13 0 0 13 0 0 0 0 0 0 0 0 0 13 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _