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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOS1
All Species:
18.18
Human Site:
S274
Identified Species:
57.14
UniProt:
Q07889
Number Species:
7
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07889
NP_005624.2
1333
152464
S274
V
E
M
T
D
E
G
S
P
H
P
L
V
G
S
Chimpanzee
Pan troglodytes
XP_515425
1598
179688
S539
V
E
M
T
D
E
G
S
P
H
P
L
V
G
S
Rhesus Macaque
Macaca mulatta
XP_001103238
1312
149667
S249
V
E
M
T
D
E
G
S
P
H
P
L
V
G
S
Dog
Lupus familis
XP_540157
1342
152915
S283
V
E
M
T
D
E
G
S
P
H
P
L
V
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q62245
1319
150865
S274
V
E
M
T
D
E
G
S
P
H
P
L
V
G
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509981
1303
148422
G314
E
L
S
V
K
L
L
G
H
I
E
D
T
V
E
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26675
1596
177916
E318
D
V
I
E
M
S
Q
E
Q
S
A
P
C
V
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782335
1310
150821
N272
M
E
M
M
D
D
S
N
S
F
L
G
I
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.3
95.7
96.8
N.A.
96.6
N.A.
N.A.
87.4
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
N.A.
50.5
Protein Similarity:
100
83.4
96.3
97.6
N.A.
97.9
N.A.
N.A.
90.3
N.A.
N.A.
N.A.
N.A.
56.6
N.A.
N.A.
67.7
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
0
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% C
% Asp:
13
0
0
0
75
13
0
0
0
0
0
13
0
0
0
% D
% Glu:
13
75
0
13
0
63
0
13
0
0
13
0
0
0
25
% E
% Phe:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
63
13
0
0
0
13
0
75
13
% G
% His:
0
0
0
0
0
0
0
0
13
63
0
0
0
0
0
% H
% Ile:
0
0
13
0
0
0
0
0
0
13
0
0
13
0
0
% I
% Lys:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
13
0
0
0
13
13
0
0
0
13
63
0
0
0
% L
% Met:
13
0
75
13
13
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
63
0
63
13
0
0
0
% P
% Gln:
0
0
0
0
0
0
13
0
13
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
13
0
0
13
13
63
13
13
0
0
0
0
63
% S
% Thr:
0
0
0
63
0
0
0
0
0
0
0
0
13
0
0
% T
% Val:
63
13
0
13
0
0
0
0
0
0
0
0
63
25
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _