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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP3CA
All Species:
32.73
Human Site:
S434
Identified Species:
48
UniProt:
Q08209
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q08209
NP_000935.1
521
58688
S434
T
P
T
G
M
L
P
S
G
V
L
S
G
G
K
Chimpanzee
Pan troglodytes
XP_001168163
525
58994
S438
T
P
T
G
M
L
P
S
G
V
L
S
G
G
K
Rhesus Macaque
Macaca mulatta
XP_001108447
533
60397
T451
T
L
K
G
L
T
P
T
G
M
L
P
S
G
V
Dog
Lupus familis
XP_535672
673
74856
S586
T
P
T
G
M
L
P
S
G
V
L
S
G
G
K
Cat
Felis silvestris
Mouse
Mus musculus
P48453
525
59155
S444
T
P
T
G
M
L
P
S
G
V
L
A
G
G
R
Rat
Rattus norvegicus
P63329
521
58625
S434
T
P
T
G
M
L
P
S
G
V
L
S
G
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507011
444
50170
T366
V
L
S
G
G
K
Q
T
L
Q
S
A
T
V
E
Chicken
Gallus gallus
P48463
309
35545
A231
I
S
E
T
F
N
H
A
N
G
L
T
L
V
S
Frog
Xenopus laevis
NP_001080813
518
58366
S434
T
P
T
G
M
L
P
S
G
V
L
S
G
G
K
Zebra Danio
Brachydanio rerio
NP_001017856
511
57796
S424
T
P
T
G
M
L
P
S
G
V
L
S
G
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27889
570
63082
K492
S
E
S
V
L
Q
L
K
G
L
T
P
T
G
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XTT8
321
36288
F242
L
F
C
E
N
N
D
F
L
R
I
C
R
A
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P22198
316
35745
D237
S
E
F
L
E
K
H
D
L
D
L
I
C
R
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P48484
321
36353
S243
T
F
G
P
D
K
V
S
E
F
L
T
K
H
D
Baker's Yeast
Sacchar. cerevisiae
P14747
604
68509
V512
L
R
N
K
I
L
A
V
A
K
V
S
R
M
Y
Red Bread Mold
Neurospora crassa
Q05681
558
63895
R467
S
R
V
F
Q
V
L
R
E
E
S
E
R
V
T
Conservation
Percent
Protein Identity:
100
98.6
95.8
77.4
N.A.
83.2
99.6
N.A.
84.2
27.2
95.3
84.6
N.A.
70.8
N.A.
29.1
N.A.
Protein Similarity:
100
99
95.8
77.4
N.A.
92.1
99.8
N.A.
85
38.5
97.8
91.9
N.A.
79.1
N.A.
40.8
N.A.
P-Site Identity:
100
100
40
100
N.A.
86.6
100
N.A.
6.6
6.6
100
100
N.A.
13.3
N.A.
0
N.A.
P-Site Similarity:
100
100
60
100
N.A.
100
100
N.A.
33.3
20
100
100
N.A.
40
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
28
N.A.
27.8
42.7
54.1
Protein Similarity:
N.A.
41.6
N.A.
39.3
59.6
67.2
P-Site Identity:
N.A.
6.6
N.A.
20
13.3
0
P-Site Similarity:
N.A.
13.3
N.A.
26.6
26.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
7
7
0
0
13
0
7
13
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
7
7
0
0
% C
% Asp:
0
0
0
0
7
0
7
7
0
7
0
0
0
0
7
% D
% Glu:
0
13
7
7
7
0
0
0
13
7
0
7
0
0
7
% E
% Phe:
0
13
7
7
7
0
0
7
0
7
0
0
0
0
0
% F
% Gly:
0
0
7
57
7
0
0
0
57
7
0
0
44
57
0
% G
% His:
0
0
0
0
0
0
13
0
0
0
0
0
0
7
7
% H
% Ile:
7
0
0
0
7
0
0
0
0
0
7
7
0
0
0
% I
% Lys:
0
0
7
7
0
19
0
7
0
7
0
0
7
0
38
% K
% Leu:
13
13
0
7
13
50
13
0
19
7
69
0
7
0
0
% L
% Met:
0
0
0
0
44
0
0
0
0
7
0
0
0
7
0
% M
% Asn:
0
0
7
0
7
13
0
0
7
0
0
0
0
0
0
% N
% Pro:
0
44
0
7
0
0
50
0
0
0
0
13
0
0
0
% P
% Gln:
0
0
0
0
7
7
7
0
0
7
0
0
0
0
0
% Q
% Arg:
0
13
0
0
0
0
0
7
0
7
0
0
19
7
7
% R
% Ser:
19
7
13
0
0
0
0
50
0
0
13
44
7
0
7
% S
% Thr:
57
0
44
7
0
7
0
13
0
0
7
13
13
0
7
% T
% Val:
7
0
7
7
0
7
7
7
0
44
7
0
0
19
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _