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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP3CA
All Species:
27.27
Human Site:
S462
Identified Species:
40
UniProt:
Q08209
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q08209
NP_000935.1
521
58688
S462
D
E
A
I
K
G
F
S
P
Q
H
K
I
T
S
Chimpanzee
Pan troglodytes
XP_001168163
525
58994
S466
D
E
A
I
K
G
F
S
P
Q
H
K
I
T
S
Rhesus Macaque
Macaca mulatta
XP_001108447
533
60397
I479
G
F
S
P
Q
H
K
I
T
S
F
E
E
A
K
Dog
Lupus familis
XP_535672
673
74856
S614
D
E
A
I
K
G
F
S
P
Q
H
K
I
T
S
Cat
Felis silvestris
Mouse
Mus musculus
P48453
525
59155
S472
E
K
A
I
R
G
F
S
P
P
H
R
I
C
S
Rat
Rattus norvegicus
P63329
521
58625
S462
D
E
A
I
K
G
F
S
P
Q
H
K
I
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507011
444
50170
E394
Q
H
K
I
T
S
F
E
E
A
K
G
L
D
R
Chicken
Gallus gallus
P48463
309
35545
I259
H
D
R
N
V
V
T
I
F
S
A
P
N
Y
C
Frog
Xenopus laevis
NP_001080813
518
58366
S462
D
E
A
I
K
G
F
S
P
Q
H
K
I
T
S
Zebra Danio
Brachydanio rerio
NP_001017856
511
57796
E452
V
E
E
V
K
D
G
E
A
I
R
G
F
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27889
570
63082
S520
K
N
A
M
Q
G
F
S
P
N
H
K
I
T
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XTT8
321
36288
A270
R
V
V
T
V
W
S
A
P
N
Y
C
Y
R
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P22198
316
35745
S265
R
Q
L
V
T
I
F
S
A
P
N
Y
C
G
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P48484
321
36353
R271
G
Y
E
F
F
A
D
R
Q
L
V
T
V
F
S
Baker's Yeast
Sacchar. cerevisiae
P14747
604
68509
L540
K
D
H
N
S
G
V
L
P
R
G
A
L
S
N
Red Bread Mold
Neurospora crassa
Q05681
558
63895
G495
T
L
M
L
G
A
E
G
I
K
N
A
I
S
S
Conservation
Percent
Protein Identity:
100
98.6
95.8
77.4
N.A.
83.2
99.6
N.A.
84.2
27.2
95.3
84.6
N.A.
70.8
N.A.
29.1
N.A.
Protein Similarity:
100
99
95.8
77.4
N.A.
92.1
99.8
N.A.
85
38.5
97.8
91.9
N.A.
79.1
N.A.
40.8
N.A.
P-Site Identity:
100
100
0
100
N.A.
60
100
N.A.
13.3
0
100
13.3
N.A.
66.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
20
100
N.A.
86.6
100
N.A.
20
6.6
100
26.6
N.A.
80
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
28
N.A.
27.8
42.7
54.1
Protein Similarity:
N.A.
41.6
N.A.
39.3
59.6
67.2
P-Site Identity:
N.A.
13.3
N.A.
6.6
13.3
13.3
P-Site Similarity:
N.A.
33.3
N.A.
13.3
46.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
44
0
0
13
0
7
13
7
7
13
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
7
7
13
% C
% Asp:
32
13
0
0
0
7
7
0
0
0
0
0
0
7
0
% D
% Glu:
7
38
13
0
0
0
7
13
7
0
0
7
7
0
7
% E
% Phe:
0
7
0
7
7
0
57
0
7
0
7
0
7
7
0
% F
% Gly:
13
0
0
0
7
50
7
7
0
0
7
13
0
7
0
% G
% His:
7
7
7
0
0
7
0
0
0
0
44
0
0
0
0
% H
% Ile:
0
0
0
44
0
7
0
13
7
7
0
0
50
0
0
% I
% Lys:
13
7
7
0
38
0
7
0
0
7
7
38
0
0
7
% K
% Leu:
0
7
7
7
0
0
0
7
0
7
0
0
13
0
0
% L
% Met:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
13
0
0
0
0
0
13
13
0
7
0
7
% N
% Pro:
0
0
0
7
0
0
0
0
57
13
0
7
0
0
7
% P
% Gln:
7
7
0
0
13
0
0
0
7
32
0
0
0
0
0
% Q
% Arg:
13
0
7
0
7
0
0
7
0
7
7
7
0
7
7
% R
% Ser:
0
0
7
0
7
7
7
50
0
13
0
0
0
19
57
% S
% Thr:
7
0
0
7
13
0
7
0
7
0
0
7
0
38
0
% T
% Val:
7
7
7
13
13
7
7
0
0
0
7
0
7
0
0
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
7
7
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _