Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPP3CA All Species: 20
Human Site: S492 Identified Species: 29.33
UniProt: Q08209 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q08209 NP_000935.1 521 58688 S492 P R R D A M P S D A N L N S I
Chimpanzee Pan troglodytes XP_001168163 525 58994 S496 P R R D A M P S D A N L N S I
Rhesus Macaque Macaca mulatta XP_001108447 533 60397 S504 P R R D A M P S D A N L N S I
Dog Lupus familis XP_535672 673 74856 S644 P R R D A M P S D A N L N S I
Cat Felis silvestris
Mouse Mus musculus P48453 525 59155 R496 I N E R M P P R K D A V Q Q D
Rat Rattus norvegicus P63329 521 58625 S492 P R R D A M P S D A N L N S I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507011 444 50170 D416 R R D A M P S D A N L N S I N
Chicken Gallus gallus P48463 309 35545 T281 A I M E L D D T L K Y S F L Q
Frog Xenopus laevis NP_001080813 518 58366 R487 N E R M P P R R D A M P S D A
Zebra Danio Brachydanio rerio NP_001017856 511 57796 P481 R I N E R M P P R R D V V N S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27889 570 63082 P542 D A V N E R M P P R R D Q P P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9XTT8 321 36288 D292 E V T E E N I D S D P V F E V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays P22198 316 35745 C288 S V D D T L M C S F Q I L K P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P48484 321 36353 M293 F D N A G A M M S V D E N L M
Baker's Yeast Sacchar. cerevisiae P14747 604 68509 N569 A R K H D L I N E K L P P S L
Red Bread Mold Neurospora crassa Q05681 558 63895 S519 Q N E R L P P S H D E V V K M
Conservation
Percent
Protein Identity: 100 98.6 95.8 77.4 N.A. 83.2 99.6 N.A. 84.2 27.2 95.3 84.6 N.A. 70.8 N.A. 29.1 N.A.
Protein Similarity: 100 99 95.8 77.4 N.A. 92.1 99.8 N.A. 85 38.5 97.8 91.9 N.A. 79.1 N.A. 40.8 N.A.
P-Site Identity: 100 100 100 100 N.A. 6.6 100 N.A. 6.6 0 20 13.3 N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 100 100 100 N.A. 13.3 100 N.A. 13.3 13.3 26.6 40 N.A. 6.6 N.A. 20 N.A.
Percent
Protein Identity: N.A. 28 N.A. 27.8 42.7 54.1
Protein Similarity: N.A. 41.6 N.A. 39.3 59.6 67.2
P-Site Identity: N.A. 6.6 N.A. 6.6 13.3 13.3
P-Site Similarity: N.A. 20 N.A. 20 46.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 7 0 13 32 7 0 0 7 38 7 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 7 7 13 38 7 7 7 13 38 19 13 7 0 7 7 % D
% Glu: 7 7 13 19 13 0 0 0 7 0 7 7 0 7 0 % E
% Phe: 7 0 0 0 0 0 0 0 0 7 0 0 13 0 0 % F
% Gly: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 7 13 0 0 0 0 13 0 0 0 0 7 0 7 32 % I
% Lys: 0 0 7 0 0 0 0 0 7 13 0 0 0 13 0 % K
% Leu: 0 0 0 0 13 13 0 0 7 0 13 32 7 13 7 % L
% Met: 0 0 7 7 13 38 19 7 0 0 7 0 0 0 13 % M
% Asn: 7 13 13 7 0 7 0 7 0 7 32 7 38 7 7 % N
% Pro: 32 0 0 0 7 25 50 13 7 0 7 13 7 7 13 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 7 0 13 7 7 % Q
% Arg: 13 44 38 13 7 7 7 13 7 13 7 0 0 0 0 % R
% Ser: 7 0 0 0 0 0 7 38 19 0 0 7 13 38 7 % S
% Thr: 0 0 7 0 7 0 0 7 0 0 0 0 0 0 0 % T
% Val: 0 13 7 0 0 0 0 0 0 7 0 25 13 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _