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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP3CA
All Species:
38.48
Human Site:
Y258
Identified Species:
56.44
UniProt:
Q08209
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q08209
NP_000935.1
521
58688
Y258
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Chimpanzee
Pan troglodytes
XP_001168163
525
58994
V262
G
C
F
S
F
L
F
V
S
G
S
Y
P
A
V
Rhesus Macaque
Macaca mulatta
XP_001108447
533
60397
Y280
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Dog
Lupus familis
XP_535672
673
74856
Y410
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Cat
Felis silvestris
Mouse
Mus musculus
P48453
525
59155
Y267
N
T
V
R
G
C
S
Y
F
Y
N
Y
P
A
V
Rat
Rattus norvegicus
P63329
521
58625
Y258
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507011
444
50170
L198
F
L
Q
H
N
N
L
L
S
I
L
R
A
H
E
Chicken
Gallus gallus
P48463
309
35545
H63
G
D
V
H
G
Q
F
H
D
L
M
E
L
F
R
Frog
Xenopus laevis
NP_001080813
518
58366
Y258
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Zebra Danio
Brachydanio rerio
NP_001017856
511
57796
Y247
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27889
570
63082
Y324
N
S
V
R
G
C
S
Y
F
Y
S
Y
A
A
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XTT8
321
36288
E74
G
Q
F
H
D
L
M
E
L
F
R
V
G
G
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P22198
316
35745
L69
V
H
G
Q
Y
S
D
L
L
R
L
F
D
Y
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P48484
321
36353
D74
A
P
I
K
I
C
G
D
I
H
G
Q
Y
S
D
Baker's Yeast
Sacchar. cerevisiae
P14747
604
68509
Y336
N
S
V
R
G
C
S
Y
A
F
T
Y
R
A
A
Red Bread Mold
Neurospora crassa
Q05681
558
63895
Y296
N
H
V
R
G
C
S
Y
F
F
S
Y
S
A
A
Conservation
Percent
Protein Identity:
100
98.6
95.8
77.4
N.A.
83.2
99.6
N.A.
84.2
27.2
95.3
84.6
N.A.
70.8
N.A.
29.1
N.A.
Protein Similarity:
100
99
95.8
77.4
N.A.
92.1
99.8
N.A.
85
38.5
97.8
91.9
N.A.
79.1
N.A.
40.8
N.A.
P-Site Identity:
100
33.3
100
100
N.A.
93.3
100
N.A.
0
13.3
100
100
N.A.
80
N.A.
0
N.A.
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
0
20
100
100
N.A.
86.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
28
N.A.
27.8
42.7
54.1
Protein Similarity:
N.A.
41.6
N.A.
39.3
59.6
67.2
P-Site Identity:
N.A.
0
N.A.
6.6
60
73.3
P-Site Similarity:
N.A.
13.3
N.A.
33.3
80
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
7
0
0
0
13
69
13
% A
% Cys:
0
7
0
0
0
69
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
7
0
0
7
0
7
7
7
0
0
0
7
0
7
% D
% Glu:
0
0
0
0
0
0
0
7
0
0
0
7
0
0
7
% E
% Phe:
7
0
13
0
7
0
13
0
57
19
0
7
0
7
0
% F
% Gly:
19
0
7
0
69
0
7
0
0
7
7
0
7
7
7
% G
% His:
0
13
0
19
0
0
0
7
0
7
0
0
0
7
0
% H
% Ile:
0
0
7
0
7
0
0
0
7
7
0
0
0
0
0
% I
% Lys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
7
0
0
0
13
7
13
13
7
13
0
7
0
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% M
% Asn:
63
0
0
0
7
7
0
0
0
0
7
0
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
0
0
0
50
0
0
% P
% Gln:
0
7
7
7
0
7
0
0
0
0
0
7
0
0
0
% Q
% Arg:
0
0
0
63
0
0
0
0
0
7
7
7
7
0
7
% R
% Ser:
0
13
0
7
0
7
63
0
13
0
57
0
7
7
7
% S
% Thr:
0
44
0
0
0
0
0
0
0
0
7
0
0
0
0
% T
% Val:
7
0
69
0
0
0
0
7
0
0
0
7
0
0
50
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
63
0
50
0
69
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _