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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADCY2 All Species: 30.61
Human Site: S350 Identified Species: 61.21
UniProt: Q08462 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q08462 NP_065433.2 1091 123603 S350 C V S G L P I S L P N H A K N
Chimpanzee Pan troglodytes XP_509874 1077 119824 S333 C V S G L P L S L P D H A I N
Rhesus Macaque Macaca mulatta XP_001083524 1091 123478 S350 C V S G L P I S L P N H A K N
Dog Lupus familis XP_535798 1051 118761 S311 C V S G L P I S L P N H A K N
Cat Felis silvestris
Mouse Mus musculus Q80TL1 1090 123251 S349 C V S G L P I S L P N H A K N
Rat Rattus norvegicus P26769 1090 123297 S349 C V S G L P I S L P N H A K N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519046 1069 121143 S329 C V S G L P I S L P N H A K N
Chicken Gallus gallus Q9DGG6 1334 149273 P443 C V A G C P E P R A D H A Y C
Frog Xenopus laevis P98999 1305 145393 P448 C V A G C P E P R P D H A Y C
Zebra Danio Brachydanio rerio NP_001093457 1139 128958 P397 C V S G L P D P L L D H A K N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VW60 1307 142798 S377 C V S G L P I S R P Q H A T N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780688 889 100312 V233 S C G V P G R V H I T Q A T L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 55.3 99.2 93.3 N.A. 94.4 94.5 N.A. 86.8 26.7 27.5 75.3 N.A. 34.6 N.A. N.A. 39.4
Protein Similarity: 100 71 99.7 94.9 N.A. 96.4 96.6 N.A. 91.9 44 44.7 84.1 N.A. 51.1 N.A. N.A. 53.3
P-Site Identity: 100 80 100 100 N.A. 100 100 N.A. 100 40 46.6 73.3 N.A. 80 N.A. N.A. 6.6
P-Site Similarity: 100 93.3 100 100 N.A. 100 100 N.A. 100 53.3 60 80 N.A. 80 N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 0 0 0 0 0 0 9 0 0 100 0 0 % A
% Cys: 92 9 0 0 17 0 0 0 0 0 0 0 0 0 17 % C
% Asp: 0 0 0 0 0 0 9 0 0 0 34 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 92 0 9 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 9 0 0 92 0 0 0 % H
% Ile: 0 0 0 0 0 0 59 0 0 9 0 0 0 9 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 59 0 % K
% Leu: 0 0 0 0 75 0 9 0 67 9 0 0 0 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 50 0 0 0 75 % N
% Pro: 0 0 0 0 9 92 0 25 0 75 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % Q
% Arg: 0 0 0 0 0 0 9 0 25 0 0 0 0 0 0 % R
% Ser: 9 0 75 0 0 0 0 67 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 9 0 0 17 0 % T
% Val: 0 92 0 9 0 0 0 9 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _