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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPIRE1
All Species:
19.39
Human Site:
Y585
Identified Species:
47.41
UniProt:
Q08AE8
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q08AE8
NP_001122098.1
756
85554
Y585
Y
Q
Q
Y
K
D
I
Y
T
A
L
K
K
G
K
Chimpanzee
Pan troglodytes
XP_511239
622
69289
E452
D
L
A
Q
L
R
S
E
V
A
S
G
L
Q
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_547684
694
79449
T524
Q
Q
Y
K
D
V
Y
T
A
L
K
K
G
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q52KF3
598
68432
Y427
Y
Q
Q
Y
K
D
V
Y
T
A
L
K
K
G
K
Rat
Rattus norvegicus
NP_001100851
749
85230
Y578
Y
Q
Q
Y
K
D
V
Y
T
A
L
K
K
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508511
680
77934
T510
Q
Q
Y
K
E
V
Y
T
A
L
K
K
G
K
L
Chicken
Gallus gallus
XP_419119
750
85408
Y579
Y
Q
Q
Y
K
D
V
Y
T
A
L
K
K
G
K
Frog
Xenopus laevis
NP_001086543
642
73882
I472
K
V
R
P
V
P
T
I
A
E
L
V
P
T
R
Zebra Danio
Brachydanio rerio
Q1LYM3
761
85865
Y586
F
Q
Q
Y
K
D
I
Y
N
A
L
K
K
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U1K1
1020
114849
E735
P
M
D
V
R
V
K
E
D
V
E
K
R
R
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.7
N.A.
81
N.A.
73.2
82.9
N.A.
73.8
81
29.8
61.8
N.A.
26.7
N.A.
N.A.
N.A.
Protein Similarity:
100
51.4
N.A.
85.9
N.A.
76.5
87
N.A.
77.6
87.4
47
73.9
N.A.
41.4
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
N.A.
13.3
N.A.
93.3
93.3
N.A.
13.3
93.3
6.6
86.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
N.A.
13.3
N.A.
100
100
N.A.
20
100
20
93.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
30
60
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
0
10
50
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
0
20
0
10
10
0
0
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
20
50
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
20
10
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
20
50
0
10
0
0
0
20
80
50
20
50
% K
% Leu:
0
10
0
0
10
0
0
0
0
20
60
0
10
0
20
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
10
0
0
10
0
10
0
0
0
0
0
0
10
0
0
% P
% Gln:
20
70
50
10
0
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
10
0
10
10
0
0
0
0
0
0
10
10
10
% R
% Ser:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
10
% S
% Thr:
0
0
0
0
0
0
10
20
40
0
0
0
0
10
0
% T
% Val:
0
10
0
10
10
30
30
0
10
10
0
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
40
0
20
50
0
0
20
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _