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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCC8 All Species: 12.42
Human Site: S745 Identified Species: 27.33
UniProt: Q09428 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q09428 NP_000343.2 1581 177008 S745 F W S S L P D S E I G E D P S
Chimpanzee Pan troglodytes XP_508310 1551 173975 S715 F W S S L P D S E I G E D P S
Rhesus Macaque Macaca mulatta XP_001088694 1581 176783 S745 F W S S L P D S E T G E D A S
Dog Lupus familis XP_542520 1543 172550 E745 F W N S S L P E E T G E D P S
Cat Felis silvestris
Mouse Mus musculus P70170 1546 174220 K725 E M Q T L E G K V Y W N N V N
Rat Rattus norvegicus Q09429 1582 177166 S746 W N S S L P D S E G E D P S N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5F364 1525 170953 K681 V G Q V G C G K S S L L S A L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001166118 1581 177105 T744 V I W N R M P T L D A E G N E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91660 1290 143990 G502 V R Q N I L F G Q P M D S Q R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q7GB25 1514 168556 I677 I L G E I P K I S G E V R I C
Baker's Yeast Sacchar. cerevisiae P39109 1515 171103 K669 V G K V G S G K T A L L S C M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.9 98.4 92.7 N.A. 67.3 95.6 N.A. N.A. 31.8 N.A. 76.2 N.A. 29.4 N.A. N.A. N.A.
Protein Similarity: 100 97.3 98.9 94.6 N.A. 79.9 97.1 N.A. N.A. 52 N.A. 85.1 N.A. 46.8 N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 60 N.A. 6.6 46.6 N.A. N.A. 0 N.A. 6.6 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 86.6 66.6 N.A. 26.6 66.6 N.A. N.A. 0 N.A. 20 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.4 29.6 N.A.
Protein Similarity: N.A. N.A. N.A. 51.9 52.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 10 10 0 0 19 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 10 % C
% Asp: 0 0 0 0 0 0 37 0 0 10 0 19 37 0 0 % D
% Glu: 10 0 0 10 0 10 0 10 46 0 19 46 0 0 10 % E
% Phe: 37 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % F
% Gly: 0 19 10 0 19 0 28 10 0 19 37 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 10 0 0 19 0 0 10 0 19 0 0 0 10 0 % I
% Lys: 0 0 10 0 0 0 10 28 0 0 0 0 0 0 0 % K
% Leu: 0 10 0 0 46 19 0 0 10 0 19 19 0 0 10 % L
% Met: 0 10 0 0 0 10 0 0 0 0 10 0 0 0 10 % M
% Asn: 0 10 10 19 0 0 0 0 0 0 0 10 10 10 19 % N
% Pro: 0 0 0 0 0 46 19 0 0 10 0 0 10 28 0 % P
% Gln: 0 0 28 0 0 0 0 0 10 0 0 0 0 10 0 % Q
% Arg: 0 10 0 0 10 0 0 0 0 0 0 0 10 0 10 % R
% Ser: 0 0 37 46 10 10 0 37 19 10 0 0 28 10 37 % S
% Thr: 0 0 0 10 0 0 0 10 10 19 0 0 0 0 0 % T
% Val: 37 0 0 19 0 0 0 0 10 0 0 10 0 10 0 % V
% Trp: 10 37 10 0 0 0 0 0 0 0 10 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _